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lutetium (177Lu) oxodotreotide

Ligand Summary
Description
Lutetium Lu 177 dotatate binds to somatostatin receptors with highest affinity for subtype 2 receptors (SSTR2). Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor-positive tumors, the compound is internalized. The beta emission from Lu 177 induces cellular damage by formation of free radicals in somatostatin receptor-positive cells and in neighboring cells.
Synonyms & Links
DrugCentral: 5275
LyCHI:  lutetium (177Lu) oxodotreotide