lumacaftor
Lumacaftor improves the conformational stability of F508del-CFTR, resulting in increased processing and trafficking of mature protein to the cell surface.
Ligand Summary
UNII: EGP8L81APK
PubChem: 16678941
ChEMBL: CHEMBL2103870
DrugCentral: 5010
LyCHI: D77H12SA6VK3
Target Activities
CFTR
Cystic fibrosis transmembrane conductance regulator
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.59 | Eur J Med Chem, (2018) 144:None:179 | ||||
EC50 | 5.58 | J. Med. Chem., (2015) 58:24:9697 | ||||
EC50 | 5.58 | Eur J Med Chem, (2018) 144:None:179 | ||||
EC50 | 5.58 | Eur J Med Chem, (2019) 180:None:430 | ||||
EC50 | 6.46 | PHARMACOLOGICAL CHAPERONE | ||||