losartan
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
Ligand Summary
Target Activities
Items per page:
10
1 – 3 of 3
AGTR1
Type-1 angiotensin II receptor
17 Activities
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1 – 10 of 17
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.06 | J. Med. Chem., (1995) 38:19:3741 | ||||
IC50 | 7.54 | Eur. J. Med. Chem., (2015) 103:None:473 | ||||
IC50 | 7.55 | J. Med. Chem., (2004) 47:4:888 | ||||
Ki | 7.77 | J. Med. Chem., (2016) 59:5:1925 | ||||
IC50 | 7.79 | MedChemComm, (2015) 6:8:1479 | ||||
IC50 | 7.79 | Eur. J. Med. Chem., (2012) 49:None:183 | ||||
IC50 | 7.79 | Bioorg. Med. Chem., (2012) 20:14:4208 | ||||
IC50 | 7.79 | Eur. J. Med. Chem., (2013) 69:None:44 | ||||
Ki | 7.92 | J. Med. Chem., (2016) 59:5:1925 | ||||
IC50 | 8.1 | Bioorg. Med. Chem. Lett., (1994) 4:1:29 | ||||
ACE
Angiotensin-converting enzyme
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.72 | J. Med. Chem., (2000) 43:3:305 | ||||
AGTR2
Type-2 angiotensin II receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.43 | |||||