losartan
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
Ligand Summary
Target Activities
AGTR1
Type-1 angiotensin II receptor
19 Activities
Items per page:
1 – 10 of 19
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.48 | Bioorg. Med. Chem., (2012) 20:14:4208 | ||||
IC50 | 8.49 | Bioorg. Med. Chem., (2016) 24:18:4444 | ||||
Kd | 8.48 | Bioorg. Med. Chem., (2010) 18:24:8418 | ||||
Ki | 8.3 | ACS Med Chem Lett, (2019) 10:1:86 | ||||
IC50 | 8.26 | Bioorg. Med. Chem. Lett., (1994) 4:18:2229 | ||||
IC50 | 8.25 | Eur. J. Med. Chem., (2012) 55:None:358 | ||||
IC50 | 8.25 | Eur. J. Med. Chem., (2013) 62:None:352 | ||||
IC50 | 8.22 | Eur. J. Med. Chem., (2012) 55:None:358 | ||||
IC50 | 8.1 | Bioorg. Med. Chem. Lett., (1994) 4:1:29 | ||||
Ki | 7.92 | J. Med. Chem., (2016) 59:5:1925 | ||||
SLCO1B1
Solute carrier organic anion transporter family member 1B1
2 Activities
AGTR2
Type-2 angiotensin II receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.72 | J. Med. Chem., (2011) 54:8:2529 | ||||
Kd | 8.43 | |||||
ACE
Angiotensin-converting enzyme
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.72 | J. Med. Chem., (2000) 43:3:305 | ||||
SLCO1B3
Solute carrier organic anion transporter family member 1B3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.05 | Mol. Pharmacol., (2013) 83:6:1257 | ||||