levothyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Ligand Summary
UNII: Q51BO43MG4
PubChem: 25201348
PubChem: 5819
Guide to Pharmacology: 2635
ChEMBL: CHEMBL1624
DrugCentral: 2646
LyCHI: YGYNAQAA9L6S
Target Activities
THRB
Thyroid hormone receptor beta
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 8.52 | |||||
IC50 | 8.52 | AGONIST | ||||
THRA
Thyroid hormone receptor alpha
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7.72 | J Med Chem, (2020) 63:13:6727 | ||||
AGONIST | ||||||