Pharos : Ligand Details - levorphanol

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A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: 27618J1N2X

PubChem: 5359272

PubChem: 53324694

Guide to Pharmacology: 7595

ChEMBL: CHEMBL592

ChEMBL: CHEMBL1628243

DrugCentral: 1574

LyCHI: 1U43KCX12F39

Target Activities

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10

1 – 4 of 4

OPRD1

Tclin

Delta-type opioid receptor

11 Activities

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1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.29		J. Med. Chem., (2003) 46:1:34	12502358

Ki	8.38		J. Med. Chem., (2006) 49:1:256	16392810

Ki	8.38		J. Med. Chem., (2003) 46:24:5162	14613319

Ki	8.38		Bioorg. Med. Chem. Lett., (2001) 11:20:2735	11591513

Ki	8.38		J. Med. Chem., (2004) 47:8:1886	15055988

Ki	8.38		J. Med. Chem., (2004) 47:1:165	14695830

Ki	8.38		J. Med. Chem., (2012) 55:8:3878	22439881

Ki	8.38		Bioorg. Med. Chem. Lett., (2007) 17:6:1508	17276685

Ki	8.38		Bioorg. Med. Chem. Lett., (2008) 18:16:4474	18674902

Ki	8.38		J. Med. Chem., (2000) 43:1:114	10633042

OPRM1

Tclin

Mu-type opioid receptor

9 Activities

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1 – 9 of 9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.68		J. Med. Chem., (2006) 49:1:256	16392810

Ki	9.68		J. Med. Chem., (2003) 46:24:5162	14613319

Ki	9.68		J. Med. Chem., (2004) 47:8:1886	15055988

Ki	9.68		J. Med. Chem., (2012) 55:8:3878	22439881

Ki	9.68		Bioorg. Med. Chem. Lett., (2007) 17:6:1508	17276685

Ki	9.68		Bioorg. Med. Chem. Lett., (2008) 18:16:4474	18674902

IC50	9.89		J. Med. Chem., (2003) 46:1:34	12502358

IC50	9.89000034			12502358

Ki	9.68	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL592

OPRK1

Tclin

Kappa-type opioid receptor

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.4		J. Med. Chem., (2003) 46:1:34	12502358

Ki	8.64		J. Med. Chem., (2006) 49:1:256	16392810

Ki	8.64		J. Med. Chem., (2003) 46:24:5162	14613319

Ki	8.64		J. Med. Chem., (2004) 47:8:1886	15055988

Ki	8.64		J. Med. Chem., (2012) 55:8:3878	22439881

Ki	8.64		Bioorg. Med. Chem. Lett., (2007) 17:6:1508	17276685

Ki	8.64		Bioorg. Med. Chem. Lett., (2008) 18:16:4474	18674902

GRIN2C

Tclin

Glutamate receptor ionotropic, NMDA 2C

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.21999979			17303642