Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

CYP3A4

Tclin

Cytochrome P450 3A4

75 Activities

Items per page:

1 – 10 of 75

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7		25923589

IC50	9	J. Med. Chem., (2016) 59:7:3340	26962886

IC50	8.4	Bioorg. Med. Chem. Lett., (2009) 19:18:5376	19679475

IC50	8.4	J. Med. Chem., (2016) 59:7:3340	26962886

Ki	8.15	Drug Metab. Dispos., (2013) 41:4:814	23355637

IC50	8.13	J Med Chem, (2016) 59:18:8535	27548392

IC50	8.11	J. Nat. Prod., (2011) 74:1:102	21138310

IC50	8.04	J Med Chem, (2016) 59:18:8535	27548392

IC50	8.01	Drug Metab. Dispos., (2013) 41:4:814	23355637

IC50	7.96	J. Med. Chem., (2010) 53:10:3887	20429511

CYP17A1

Tclin

Steroid 17-alpha-hydroxylase/17,20 lyase

23 Activities

Items per page:

1 – 10 of 23

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.58	J. Med. Chem., (1995) 38:13:2463	7608911

IC50	7.58	J. Med. Chem., (1995) 38:21:4191	7473546

IC50	7.58	J. Med. Chem., (1996) 39:17:3319	8765515

Ki	7.42	J. Med. Chem., (1998) 41:6:902	9526564

Ki	7.42	J. Med. Chem., (2015) 58:5:2077	25591066

IC50	7.32	Bioorg Med Chem Lett, (2016) 26:23:5825	27789139

IC50	7.19	J. Med. Chem., (1996) 39:17:3319	8765515

IC50	7.19	J. Med. Chem., (1995) 38:13:2463	7608911

IC50	7.19	J. Med. Chem., (1995) 38:21:4191	7473546

IC50	7.14	J. Med. Chem., (2008) 51:16:5009	18672868

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.94	Bioorg Med Chem Lett, (2016) 26:23:5825	27789139

IC50	6.9	J. Med. Chem., (2008) 51:16:5009	18672868

IC50	6.9	J. Med. Chem., (2010) 53:13:5049	20550118

IC50	6.9	ACS Med. Chem. Lett., (2011) 2:1:2	24900247

IC50	6.9	ACS Med. Chem. Lett., (2011) 2:8:559	24900349

IC50	6.9	None, (2016) None:None:None

IC50	6.65	J. Med. Chem., (2005) 48:5:1563	15743198

IC50	6.65	J. Med. Chem., (2005) 48:21:6632	16220979

IC50	6.65	J. Med. Chem., (2006) 49:7:2222	16570918

IC50	6.65	None, (2016) None:None:None

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.17	J. Med. Chem., (2008) 51:16:5009	18672868

IC50	7.17	J. Med. Chem., (2010) 53:13:5049	20550118

IC50	7.17	ACS Med. Chem. Lett., (2011) 2:1:2	24900247

IC50	7.17	ACS Med. Chem. Lett., (2011) 2:8:559	24900349

IC50	7.17	None, (2016) None:None:None

IC50	7.09	J. Med. Chem., (2005) 48:5:1563	15743198

IC50	7.09	J. Med. Chem., (2005) 48:21:6632	16220979

IC50	7.09	J. Med. Chem., (2006) 49:7:2222	16570918

IC50	7.09	None, (2016) None:None:None

IC50	7.09	None, (2016) None:None:None

CYP24A1

Tchem

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.48	J. Med. Chem., (2014) 57:18:7702	25148392

Ki	7.46	Eur. J. Med. Chem., (2014) 87:None:39	25240094

IC50	6.9	Bioorg. Med. Chem., (2010) 18:14:4939	20594862

IC50	6.51	J. Med. Chem., (2004) 47:27:6854	15615534

IC50	6.51	Bioorg. Med. Chem., (2010) 18:14:4939	20594862

IC50	6.33	Eur. J. Med. Chem., (2014) 87:None:39	25240094

IC50	6.33	J. Med. Chem., (2014) 57:18:7702	25148392

IC50	6.3	Bioorg Med Chem, (2017) 25:20:5629	28886997

IC50	6.3	Bioorg Med Chem, (2017) 25:15:4076	28601511

IC50	6.28	Bioorg. Med. Chem., (2010) 18:14:4939	20594862

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

6 Activities

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1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	5.72	Bioorg. Med. Chem. Lett., (2003) 13:16:2773	12873512

IC50	5.72	Bioorg. Med. Chem. Lett., (2005) 15:11:2886	15911273

IC50	5.72	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	5.72	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	5.72	Bioorg. Med. Chem., (2008) 16:11:6252	18448342

IC50	5.72	Eur. J. Med. Chem., (2011) 46:2:618	21185626

CYP19A1

Tclin

Aromatase

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.4	J. Med. Chem., (2006) 49:7:2222	16570918

IC50	7.22	Bioorg. Med. Chem. Lett., (2010) 20:10:3050	20413308

Ki	6.4	Bioorg. Med. Chem. Lett., (2012) 22:1:718	22079757

Ki	6.4	Bioorg. Med. Chem. Lett., (2012) 22:1:718	22079757

IC50	6.1	J. Nat. Prod., (2008) 71:11:1793	18939864

IC50	6.05	J. Nat. Prod., (2007) 70:3:353	17291041

CYP51A1

Tchem

Lanosterol 14-alpha demethylase

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.61	J. Med. Chem., (1993) 36:15:2235	8340925

Ki	7.2	J. Med. Chem., (1993) 36:15:2235	8340925

Kd	6.96	Bioorg. Med. Chem., (2008) 16:1:209	17964172

Kd	6.96	Antimicrob. Agents Chemother., (2009) 53:3:1157	19075057

IC50	6.72	Drug Metab. Dispos., (2007) 35:3:493	17194716

SLC6A4

Tclin

Sodium-dependent serotonin transporter

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	6.55	None, None:None:None

IC50	6.28	None, None:None:None

CYP3A5

Tclin

Cytochrome P450 3A5

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
IC50	6.92	None, (2015) None:None:None

IC50	6.92	None, (2015) None:None:None

CYP27B1

Tchem

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.47	Bioorg Med Chem, (2017) 25:20:5629	28886997

IC50	6.47	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL157101

KCNA10

Tclin

Potassium voltage-gated channel subfamily A member 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	6.3			10836990

HSP90AA1

Tchem

Heat shock protein HSP 90-alpha

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
AC50	6.36		None, None:None:None

CYP4F2

Tchem

Phylloquinone omega-hydroxylase CYP4F2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.13		Drug Metab. Dispos., (2011) 39:2:191	21045201

ABCB1

Tchem

Multidrug resistance protein 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		J. Med. Chem., (2003) 46:9:1716	12699389