Pharos : Ligand Details - ketoconazole

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Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

PubChem: 3823

Guide to Pharmacology: 2568

ChEMBL: CHEMBL295698

ChEMBL: CHEMBL157101

DrugCentral: 1527

LyCHI: P3TD9W5HJJWL

Target Activities

CYP3A4

Tclin

Cytochrome P450 3A4

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.82		None, (2015) None:None:None

IC50	6.82		None, (2015) None:None:None

IC50	7.92		None, (2015) None:None:None

IC50	7.92		None, (2015) None:None:None

Ki	7			25923589

CYP17A1

Tclin

Steroid 17-alpha-hydroxylase/17,20 lyase

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.4		None, (2015) None:None:None

IC50	6.4		None, (2015) None:None:None

IC50	7.03		Bioorg Med Chem Lett, (2016) 26:23:5825	27789139

IC50	7.09		None, (2016) None:None:None

IC50	7.28	INHIBITOR	http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003906/WC500181492.pdf

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.65		None, (2016) None:None:None

IC50	6.65		None, (2016) None:None:None

IC50	6.9		None, (2016) None:None:None

IC50	6.89619637	INHIBITOR	http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003906/WC500181492.pdf

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.09		None, (2016) None:None:None

IC50	7.09		None, (2016) None:None:None

IC50	7.17		None, (2016) None:None:None

IC50	7.1739254	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/18672868

CYP3A5

Tclin

Cytochrome P450 3A5

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.92		None, (2015) None:None:None

IC50	6.92		None, (2015) None:None:None

KCNA10

Tclin

Potassium voltage-gated channel subfamily A member 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	6.3			10836990