ivacaftor
Ivacaftor is a potentiator of the CFTR protein. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. Ivacaftor facilitates increased chloride transport by potentiating the channel-open probability (or gating) of the CFTR protein.
Ligand Summary
UNII: 1Y740ILL1Z
PubChem: 16220172
ChEMBL: CHEMBL2010601
DrugCentral: 4228
LyCHI: S91W36X1YGJK
Target Activities
CFTR
Cystic fibrosis transmembrane conductance regulator
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.52 | J. Med. Chem., (2014) 57:23:9776 | ||||
EC50 | 8.52 | J. Med. Chem., (2014) 57:23:9774 | ||||
EC50 | 7.66 | J. Med. Chem., (2014) 57:23:9776 | ||||
EC50 | 6.63 | J. Med. Chem., (2014) 57:23:9776 | ||||
EC50 | 6.63 | J. Med. Chem., (2014) 57:23:9774 | ||||
EC50 | 5.89 | J Med Chem, (2018) 61:4:1425 | ||||
EC50 | 8.52 | POSITIVE MODULATOR | ||||