inqovi
Ligand Summary
Cedazuridine inhibits cytidine deaminase (CDA), an enzyme that catalyzes the degradation of cytidine, including the cytidine analog decitabine (a nucleoside metabolic inhibitor). Because high levels of CDA in the gastrointestinal tract and liver degrade decitabine and limit its oral bioavailability, administration of cedazuridine with decitabine increases systemic exposure of decitabine. Inqovi is a combination of decitabine and cedazuridine for treatment of adult patients with myelodysplastic syndromes (MDS).
UNII: 39IS23Q1EW
PubChem: 25267009
ChEMBL: CHEMBL3237547
DrugCentral: 5402
LyCHI: UR6HXAT2SP5G
Target Activities
2 Activities
Items per page:
10
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | INHIBITOR | |||||