indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. Additional data needed to determine whether in vitro activity against SARS-CoV-2 corresponds with clinical efficacy in the treatment of COVID-19.
Ligand Summary
UNII: XXE1CET956
PubChem: 3715
Guide to Pharmacology: 1909
ChEMBL: CHEMBL6
DrugCentral: 1440
LyCHI: AC3D4RL6RU1S
Target Activities
PTGS2
Prostaglandin G/H synthase 2
64 Activities
Items per page:
1 – 10 of 64
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.58 | |||||
IC50 | 8.23 | J. Med. Chem., (2002) 45:7:1402 | ||||
IC50 | 8.05 | J. Med. Chem., (2003) 46:16:3463 | ||||
IC50 | 8.05 | J. Med. Chem., (2001) 44:3:350 | ||||
IC50 | 8 | J. Med. Chem., (2007) 50:7:1425 | ||||
IC50 | 8 | J. Med. Chem., (2010) 53:12:4691 | ||||
IC50 | 8 | Bioorg. Med. Chem., (2011) 19:18:5372 | ||||
IC50 | 7.58 | Bioorg. Med. Chem. Lett., (1997) 7:1:47 | ||||
IC50 | 7.58 | Bioorg. Med. Chem. Lett., (1999) 9:22:3181 | ||||
IC50 | 7.58 | Bioorg. Med. Chem. Lett., (1999) 9:22:3187 | ||||
PTGS1
Prostaglandin G/H synthase 1
59 Activities
Items per page:
1 – 10 of 59
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.59 | |||||
IC50 | 8.7 | J. Med. Chem., (2003) 46:16:3463 | ||||
IC50 | 8.52 | J. Med. Chem., (2001) 44:3:350 | ||||
IC50 | 8.52 | J. Med. Chem., (2002) 45:7:1402 | ||||
IC50 | 8.3 | Bioorg. Med. Chem. Lett., (2006) 16:17:4440 | ||||
IC50 | 8.22 | J. Med. Chem., (2007) 50:7:1425 | ||||
IC50 | 8.09 | J. Med. Chem., (1999) 42:7:1151 | ||||
IC50 | 8.09 | J. Med. Chem., (1999) 42:7:1161 | ||||
IC50 | 8 | J. Nat. Prod., (2005) 68:7:985 | ||||
IC50 | 8 | ACS Med. Chem. Lett., (2011) 2:5:353 | ||||
AKR1C3
Aldo-keto reductase family 1 member C3
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | J. Med. Chem., (2013) 56:6:2429 | ||||
IC50 | 6.14 | J. Med. Chem., (2012) 55:17:7746 | ||||
IC50 | 7 | |||||
NAPRT
Nicotinate phosphoribosyltransferase
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.82 | None, None:None:None | ||||
Ki | 9.82 | |||||
Ki | 9.82 | |||||
CXCL8
Interleukin-8
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2009) 19:15:4026 | ||||
IC50 | 7.3 | |||||
MT-CO2
Cytochrome c oxidase subunit 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.21 | Eur J Med Chem, (2017) 139:None:936 | ||||
IC50 | 6.21 | |||||
PPARG
Peroxisome proliferator-activated receptor gamma
1 Activities
SLC46A1
Proton-coupled folate transporter
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 3.7 | |||||
TBXAS1
Thromboxane-A synthase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | J. Med. Chem., (1989) 32:8:1842 | ||||
ALB
Serum albumin
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.16 | J Med Chem, (2017) 60:17:7434 | ||||
PTGDR2
Prostaglandin D2 receptor 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.3 | J. Med. Chem., (2005) 48:20:6174 | ||||
AR
Androgen receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 9.85 | J. Med. Chem., (2013) 56:6:2429 | ||||