indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
Ligand Summary
UNII: XXE1CET956
PubChem: 3715
Guide to Pharmacology: 1909
ChEMBL: CHEMBL6
DrugCentral: 1440
LyCHI: AC3D4RL6RU1S
Target Activities
PTGS1
Prostaglandin G/H synthase 1
53 Activities
Items per page:
1 – 10 of 53
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.3 | J. Med. Chem., (2007) 50:25:6367 | ||||
IC50 | 6.58 | Eur. J. Med. Chem., (2008) 43:3:456 | ||||
IC50 | 6.58 | Eur. J. Med. Chem., (2010) 45:12:6027 | ||||
Kd | 6.6 | Med Chem Res, (2012) 21:11:3491 | ||||
IC50 | 6.6 | J. Med. Chem., (2000) 43:2:214 | ||||
IC50 | 6.6 | Bioorg. Med. Chem. Lett., (2009) 19:12:3271 | ||||
IC50 | 6.7 | Bioorg. Med. Chem., (2010) 18:11:3910 | ||||
IC50 | 6.7 | J. Med. Chem., (1994) 37:23:3878 | ||||
IC50 | 6.7 | Bioorg. Med. Chem. Lett., (1999) 9:13:1773 | ||||
IC50 | 6.7 | Bioorg. Med. Chem. Lett., (1999) 9:15:2207 | ||||
PTGS2
Prostaglandin G/H synthase 2
51 Activities
Items per page:
1 – 10 of 51
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.02 | Bioorg. Med. Chem. Lett., (2014) 24:1:77 | ||||
IC50 | 6.02 | Eur. J. Med. Chem., (2015) 97:None:104 | ||||
IC50 | 6.02 | Eur. J. Med. Chem., (2014) 77:None:185 | ||||
IC50 | 6.05 | Bioorg. Med. Chem. Lett., (1995) 5:8:867 | ||||
IC50 | 6.05 | J. Med. Chem., (1995) 38:22:4570 | ||||
IC50 | 6.05 | J. Med. Chem., (1996) 39:9:1846 | ||||
IC50 | 6.05 | J. Med. Chem., (1997) 40:11:1634 | ||||
IC50 | 6.05 | J. Med. Chem., (2000) 43:16:3168 | ||||
IC50 | 6.08 | None, None:None:None | ||||
IC50 | 6.12 | Bioorg. Med. Chem., (2011) 19:10:3242 | ||||
AKR1C3
Aldo-keto reductase family 1 member C3
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.14 | J. Med. Chem., (2012) 55:17:7746 | ||||
IC50 | 7 | J. Med. Chem., (2013) 56:6:2429 | ||||
IC50 | 7 | |||||
CXCL8
Interleukin-8
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2009) 19:15:4026 | ||||
IC50 | 7.3 | |||||
PTGDR2
Prostaglandin D2 receptor 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.3 | J. Med. Chem., (2005) 48:20:6174 | ||||
AR
Androgen receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 9.85 | J. Med. Chem., (2013) 56:6:2429 | ||||
PPARG
Peroxisome proliferator-activated receptor gamma
1 Activities
SLC46A1
Proton-coupled folate transporter
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 3.7 | |||||