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idelalisib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Idelalisib is an inhibitor of PI3K-delta kinase, which is expressed in normal and malignant B-cells. Idelalisib induced apoptosis and inhibited proliferation in cell lines derived from malignant B-cells and in primary tumor cells. Idelalisib inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and the CXCR4 and CXCR5 signaling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow.
Synonyms & Links
Guide to Pharmacology: 6741
DrugCentral: 4878
LyCHI:  SRSZU2MKMCYA


Target Activities