Pharos : Ligand Details - hydromorphone

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Description

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Synonyms & Links

UNII: Q812464R06

PubChem: 5284570

Guide to Pharmacology: 7082

ChEMBL: CHEMBL398707

DrugCentral: 1393

LyCHI: JLGV9NTPDPX3

Target Activities

Explore Associated and Predicted Targets

OPRM1

Tclin

Mu-type opioid receptor

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.55			19282177

Ki	9.55		Bioorg. Med. Chem. Lett., (2009) 19:8:2289	19282177

EC50	8.59		Bioorg. Med. Chem. Lett., (2009) 19:8:2289	19282177

Ki	9.55	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL398707

OPRK1

Tclin

Kappa-type opioid receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.55			19282177

Ki	8.55		Bioorg. Med. Chem. Lett., (2009) 19:8:2289	19282177

EC50	7.96		Bioorg. Med. Chem. Lett., (2009) 19:8:2289	19282177

OPRD1

Tclin

Delta-type opioid receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.42			19282177

Ki	7.42		Bioorg. Med. Chem. Lett., (2009) 19:8:2289	19282177