haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Ligand Summary
UNII: J6292F8L3D
PubChem: 3559
Guide to Pharmacology: 86
ChEMBL: CHEMBL54
DrugCentral: 1353
LyCHI: GKRULT6FAR97
Target Activities
Items per page:
10
1 – 10 of 18
DRD2
D(2) dopamine receptor
85 Activities
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1 – 10 of 85
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.75 | Bioorg. Med. Chem. Lett., (2002) 12:10:1327 | ||||
Ki | 8.02 | Bioorg. Med. Chem., (2016) 24:9:2060 | ||||
Ki | 8.07 | J. Med. Chem., (2002) 45:23:5136 | ||||
IC50 | 8.18 | None, None:None:None | ||||
Ki | 8.25 | J. Med. Chem., (2000) 43:2:270 | ||||
Ki | 8.29 | Bioorg. Med. Chem., (2008) 16:19:8875 | ||||
Ki | 8.3 | J. Med. Chem., (2007) 50:21:5103 | ||||
IC50 | 8.31 | J. Med. Chem., (1999) 42:12:2235 | ||||
Ki | 8.32 | J. Med. Chem., (1997) 40:1:1 | ||||
Ki | 8.38 | J. Med. Chem., (2008) 51:18:5813 | ||||
SIGMAR1
Sigma non-opioid intracellular receptor 1
52 Activities
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1 – 10 of 52
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.64 | Eur. J. Med. Chem., (2010) 45:1:256 | ||||
IC50 | 6.67 | J. Med. Chem., (1994) 37:24:4109 | ||||
Ki | 7.4 | J. Med. Chem., (2014) 57:7:2884 | ||||
Ki | 7.4 | J. Med. Chem., (2016) 59:11:5505 | ||||
IC50 | 7.68 | Bioorg. Med. Chem. Lett., (2013) 23:6:1834 | ||||
IC50 | 7.77 | J. Med. Chem., (1992) 35:25:4683 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:1:266 | ||||
IC50 | 7.89 | None, None:None:None | ||||
Ki | 7.92 | Eur. J. Med. Chem., (2015) 89:None:198 | ||||
Ki | 7.92 | Eur. J. Med. Chem., (2015) 92:None:575 | ||||
DRD3
D(3) dopamine receptor
46 Activities
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1 – 10 of 46
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.54 | Bioorg. Med. Chem. Lett., (2011) 21:12:3622 | ||||
Ki | 7.6 | Bioorg. Med. Chem. Lett., (2002) 12:10:1327 | ||||
Ki | 7.68 | J. Med. Chem., (2004) 47:6:1303 | ||||
IC50 | 7.7 | None, None:None:None | ||||
Ki | 7.75 | J. Med. Chem., (2005) 48:6:1705 | ||||
Ki | 7.79 | Bioorg. Med. Chem., (2014) 22:21:5838 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:25:7919 | ||||
Ki | 7.8 | J. Med. Chem., (2007) 50:20:5043 | ||||
Ki | 7.9 | Bioorg. Med. Chem., (2010) 18:14:5291 | ||||
Ki | 7.94 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
DRD4
D(4) dopamine receptor
42 Activities
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1 – 10 of 42
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.38 | Bioorg. Med. Chem. Lett., (2002) 12:10:1327 | ||||
Ki | 7.9 | Bioorg. Med. Chem., (2009) 17:4:1716 | ||||
Ki | 7.96 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.98 | Bioorg. Med. Chem. Lett., (2003) 13:21:3779 | ||||
Ki | 8 | Bioorg. Med. Chem. Lett., (2003) 13:21:3779 | ||||
Ki | 8.1 | J. Med. Chem., (2011) 54:8:2529 | ||||
Ki | 8.14 | J. Med. Chem., (1997) 40:1:1 | ||||
Ki | 8.14 | J. Med. Chem., (2004) 47:17:4155 | ||||
Ki | 8.14 | J. Med. Chem., (2005) 48:3:694 | ||||
Ki | 8.15 | J. Med. Chem., (1995) 38:25:4950 | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
14 Activities
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1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.85 | Bioorg. Med. Chem. Lett., (2004) 14:18:4771 | ||||
IC50 | 5.96 | Bioorg. Med. Chem. Lett., (2012) 22:15:5134 | ||||
Ki | 6.29 | Bioorg. Med. Chem. Lett., (2006) 16:20:5303 | ||||
IC50 | 6.64 | J. Nat. Prod., (2012) 75:6:1210 | ||||
Ki | 6.92 | J. Med. Chem., (2009) 52:1:151 | ||||
IC50 | 7.5 | Bioorg. Med. Chem. Lett., (2003) 13:10:1829 | ||||
IC50 | 7.52 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 7.52 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 7.52 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 7.55 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
HTR2A
5-hydroxytryptamine receptor 2A
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | None, (2013) None:None:None | ||||
Ki | 7 | None, (2013) None:None:None | ||||
Ki | 7 | J. Med. Chem., (2007) 50:21:5103 | ||||
IC50 | 7.12 | None, None:None:None | ||||
Ki | 7.6 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.68 | None, None:None:None | ||||
7.4 | ||||||
DRD1
D(1A) dopamine receptor
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.09 | J. Med. Chem., (2004) 47:17:4155 | ||||
Ki | 7.26 | None, None:None:None | ||||
Ki | 7.31 | J. Med. Chem., (1996) 39:14:2764 | ||||
Ki | 7.6 | Bioorg. Med. Chem. Lett., (2011) 21:12:3622 | ||||
Ki | 8.21 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
DRD5
D(1B) dopamine receptor
4 Activities
ADRA1D
Alpha-1D adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.08 | None, None:None:None | ||||
Ki | 7.39 | None, None:None:None | ||||
ADRA1A
Alpha-1A adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.96 | None, (2013) None:None:None | ||||
Ki | 7.96 | None, (2013) None:None:None | ||||