guselkumab
Ligand Summary
Guselkumab is a human monoclonal IgG1-lambda antibody that selectively binds to the p19 subunit of interleukin 23 (IL-23) and inhibits its interaction with the IL-23 receptor. IL-23 is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Guselkumab inhibits the release of proinflammatory cytokines and chemokines.
ChEMBL: CHEMBL2364648
DrugCentral: 5246
LyCHI: guselkumab
Target Activities
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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ANTIBODY BINDING | ||||||
ANTIBODY BINDING | ||||||