glutamic acid
Ligand Summary
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
UNII: 3KX376GY7L
PubChem: 33032
Guide to Pharmacology: 1369
ChEMBL: CHEMBL575060
DrugCentral: 1310
LyCHI: QNFUHWBU6GM8
Target Activities
GRM3
Metabotropic glutamate receptor 3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.4 | ||||||
7.4 | ||||||
Ki | 7.24 | MedChemComm, (2011) 2:11:1120 | ||||
EC50 | 7.22 | MedChemComm, (2011) 2:11:1120 | ||||
Ki | 7.4 | AGONIST | ||||
GRIA4
Glutamate receptor 4
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.06 | J. Med. Chem., (1997) 40:22:3645 | ||||
Ki | 6.06 | Bioorg. Med. Chem. Lett., (2000) 10:16:1807 | ||||
Ki | 6.06 | J. Med. Chem., (2000) 43:10:1958 | ||||
EC50 | 5.32 | J Med Chem, (2019) 62:9:4467 | ||||
EC50 | 5.31 | J Med Chem, (2019) 62:9:4467 | ||||
GRIA2
Glutamate receptor 2
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.03 | J. Med. Chem., (1997) 40:22:3645 | ||||
Ki | 6.03 | Bioorg. Med. Chem. Lett., (2000) 10:16:1807 | ||||
Ki | 6.03 | J. Med. Chem., (2000) 43:10:1958 | ||||
EC50 | 5.66 | Bioorg. Med. Chem., (2010) 18:4:1381 | ||||
EC50 | 5.21 | Bioorg. Med. Chem., (2010) 18:4:1381 | ||||
GRIA1
Glutamate receptor 1
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 5.87 | J. Med. Chem., (1997) 40:22:3645 | ||||
Ki | 5.87 | Bioorg. Med. Chem. Lett., (2000) 10:16:1807 | ||||
Ki | 5.87 | J. Med. Chem., (2000) 43:10:1958 | ||||
EC50 | 5.65 | Bioorg. Med. Chem., (2010) 18:4:1381 | ||||
GRM6
Metabotropic glutamate receptor 6
3 Activities
GRIK5
Glutamate receptor ionotropic, kainate 5
3 Activities
GRM7
Metabotropic glutamate receptor 7
2 Activities
GRIK1
Glutamate receptor ionotropic, kainate 1
2 Activities
SLC1A1
Excitatory amino acid transporter 3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.29 | J. Med. Chem., (2008) 51:14:4085 | ||||
Ki | 7.29 | |||||
GRIK2
Glutamate receptor ionotropic, kainate 2
2 Activities
GRIK3
Glutamate receptor ionotropic, kainate 3
2 Activities
GRM2
Metabotropic glutamate receptor 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
4.9 | ||||||
GRM5
Metabotropic glutamate receptor 5
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.1 | ||||||
GRM8
Metabotropic glutamate receptor 8
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.24 | Bioorg. Med. Chem. Lett., (2005) 15:2:349 | ||||
GRIA3
Glutamate receptor 3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.44 | Bioorg. Med. Chem., (2010) 18:4:1381 | ||||