gilteritinib
Ligand Summary
Gilteritinib is a small molecule that inhibits multiple receptor tyrosine kinases, including FMS-like tyrosine kinase 3 (FLT3). Gilteritinib demonstrated the ability to inhibit FLT3 receptor signaling and proliferation in cells exogenously expressing FLT3 including FLT3-ITD, tyrosine kinase domain mutations (TKD) FLT3-D835Y and FLT3-ITD-D835Y, and it induced apoptosis in leukemic cells expressing FLT3-ITD.
UNII: 66D92MGC8M
PubChem: 49803313
PubChem: 155520090
Guide to Pharmacology: 8708
ChEMBL: CHEMBL3301622
ChEMBL: CHEMBL4524472
DrugCentral: 5306
LyCHI: S4NDSK8XDGVU
Target Activities
55 Activities
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1 – 10 of 55
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