fostamatinib
Ligand Summary
Fostamatinib is a tyrosine kinase inhibitor with demonstrated activity against spleen tyrosine kinase (SYK). The major metabolite of fostamatinib, R406, inhibits signal transduction of Fc-activating receptors and B-cell receptor. The fostamatinib metabolite R406 reduces antibody-mediated destruction of platelets.
UNII: SQ8A3S5101
PubChem: 11671467
PubChem: 146673142
ChEMBL: CHEMBL2103830
ChEMBL: CHEMBL3989516
DrugCentral: 5280
LyCHI: YYH232CPYC1D
Target Activities
SYK
Tyrosine-protein kinase SYK
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.77 | J. Med. Chem., (2012) 55:23:10414 | ||||
IC50 | 7.77 | J. Med. Chem., (2013) 56:4:1677 | ||||
IC50 | 7.39 | INHIBITOR | ||||
ADORA3
Adenosine receptor A3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.09 | INHIBITOR | ||||