fosnetupitant
Ligand Summary
Netupitant is a selective antagonist of human substance P/neurokinin 1 (NK-1) receptors. Delayed emesis has been largely associated with the activation of tachykinin family neurokinin 1 (NK-1) receptors (broadly distributed in the central and peripheral nervous systems) by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses.
UNII: T672P80L2S
PubChem: 71544786
ChEMBL: CHEMBL3989917
DrugCentral: 5283
LyCHI: QRFLQ9M6BM6F
Target Activities
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | ANTAGONIST | |||||