Pharos : Ligand Details

Target Activities

DRD2

Tclin

D(2) dopamine receptor

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.84000015			17826096

Ki	9.27		None, None:None:None

Ki	8.84		Bioorg. Med. Chem. Lett., (2009) 19:2:538	19091563

IC50	8.79		None, None:None:None

Ki	9.269	ANTAGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL726

HRH1

Tclin

Histamine H1 receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.7		12629531

Ki	8.33	None, None:None:None

Ki	7.4	Bioorg. Med. Chem. Lett., (2009) 19:2:538	19091563

IC50	7.4	None, None:None:None

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.5		12629531

Ki	8.84	None, None:None:None

IC50	8.29	None, None:None:None

HTR6

Tchem

5-hydroxytryptamine receptor 6

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.8		7908055

Ki	7.62	None, None:None:None

IC50	7.28	None, None:None:None

DRD1

Tclin

D(1A) dopamine receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.7		1826762

Ki	7.96	None, None:None:None

IC50	7.64	None, None:None:None

DRD3

Tclin

D(3) dopamine receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.7	None, None:None:None

IC50	9.23	None, None:None:None

Ki	8.49	Bioorg. Med. Chem. Lett., (2009) 19:2:538	19091563

HTR7

Tclin

5-hydroxytryptamine receptor 7

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	7.9			15821958

	8.1			7908055

DRD5

Tchem

D(1B) dopamine receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.9		1826762

Ki	7.68	Bioorg. Med. Chem. Lett., (2009) 19:2:538	19091563

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.6	None, None:None:None

IC50	7.41	None, None:None:None

SIGMAR1

Tclin

Sigma non-opioid intracellular receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.07	None, None:None:None

IC50	7.7	None, None:None:None

ADRA1D

Tclin

Alpha-1D adrenergic receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.8	None, None:None:None

IC50	7.48	None, None:None:None

ADRA2B

Tclin

Alpha-2B adrenergic receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.89	None, None:None:None

IC50	7.54	None, None:None:None

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	5.33	None, None:None:None

IC50	5.24	None, None:None:None

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.46	None, None:None:None

IC50	7.17	None, None:None:None

ADRA2A

Tclin

Alpha-2A adrenergic receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.1		None, None:None:None

SLC6A4

Tclin

Sodium-dependent serotonin transporter

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.1		None, None:None:None

CYP1A2

Tchem

Cytochrome P450 1A2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
AC50	6		None, None:None:None

ADRA2C

Tclin

Alpha-2C adrenergic receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.66		None, None:None:None

CYP2D6

Tclin

Cytochrome P450 2D6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
AC50	6.2		None, None:None:None

KCNK2

Tclin

Potassium channel subfamily K member 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.33		J. Med. Chem., (2016) 59:11:5149	26588045