flumazenil
A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
Ligand Summary
NCATS Inxight: Drugs: flumazenil
PubChem: 3373
Guide to Pharmacology: 4192
ChEMBL: CHEMBL407
DrugCentral: 1195
LyCHI: 9WDBNLW1QLLP
Target Activities
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GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2
5 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.0969 | ALLOSTERIC ANTAGONIST | ||||
Ki | 9.0458 | ALLOSTERIC ANTAGONIST | ||||
Ki | 8.9788 | ALLOSTERIC ANTAGONIST | ||||
Ki | 9.2218 | ALLOSTERIC ANTAGONIST | ||||
Ki | 6.8297 | ALLOSTERIC ANTAGONIST | ||||
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.0969 | ALLOSTERIC ANTAGONIST | ||||
Ki | 9.0458 | ALLOSTERIC ANTAGONIST | ||||
Ki | 8.9788 | ALLOSTERIC ANTAGONIST | ||||
Ki | 9.2218 | ALLOSTERIC ANTAGONIST | ||||
Ki | 6.8297 | ALLOSTERIC ANTAGONIST | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.48 | J. Med. Chem., (2008) 51:22:7243 | ||||
Kd | 8.7 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 9.10000038 | |||||
Ki | 9.0969 | ALLOSTERIC ANTAGONIST | ||||
GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.3 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 9.22000027 | |||||
Ki | 9.2218 | ALLOSTERIC ANTAGONIST | ||||
GABRA4
Gamma-aminobutyric acid receptor subunit alpha-4
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.7 | J. Med. Chem., (2008) 51:22:7243 | ||||
Ki | 7.03000021 | |||||
Ki | 8.7 | ALLOSTERIC ANTAGONIST | ||||
GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.05000019 | |||||
Ki | 9.0458 | ALLOSTERIC ANTAGONIST | ||||
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.97999954 | |||||
Ki | 8.9788 | ALLOSTERIC ANTAGONIST | ||||
GABRA6
Gamma-aminobutyric acid receptor subunit alpha-6
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.82999992 | |||||
Ki | 6.8297 | ALLOSTERIC ANTAGONIST | ||||