flufenamic acid
An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)
Ligand Summary
NCATS Inxight: Drugs: flufenamic acid
PubChem: 3371
Guide to Pharmacology: 2447
ChEMBL: CHEMBL23588
DrugCentral: 1193
LyCHI: 4GG5L8MY9B2H
Target Activities
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10
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AKR1C3
Aldo-keto reductase family 1 member C3
5 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.39 | Eur. J. Med. Chem., (2013) 62:None:738 | ||||
IC50 | 6.39 | J. Med. Chem., (2012) 55:17:7746 | ||||
IC50 | 7.29 | None, (2016) None:None:None | ||||
IC50 | 7.29 | Bioorg. Med. Chem. Lett., (2011) 21:5:1464 | ||||
IC50 | 7.3 | J. Med. Chem., (2012) 55:5:2311 | ||||
PTGS2
Prostaglandin G/H synthase 2
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.7 | Bioorg. Med. Chem. Lett., (2012) 22:10:3492 | ||||
IC50 | 7.8 | None, (2016) None:None:None | ||||
IC50 | 7.8 | J. Med. Chem., (2012) 55:5:2311 | ||||
IC50 | 6.93 | INHIBITOR | ||||
AKR1C2
Aldo-keto reductase family 1 member C2
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.2 | None, (2016) None:None:None | ||||
IC50 | 6.43 | None, (2016) None:None:None | ||||
IC50 | 6.43 | Bioorg. Med. Chem. Lett., (2011) 21:5:1464 | ||||
IC50 | 6.43 | J. Med. Chem., (2012) 55:5:2311 | ||||
AKR1B10
Aldo-keto reductase family 1 member B10
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.12 | J. Med. Chem., (2015) 58:5:2047 | ||||
IC50 | 6.12 | J. Nat. Prod., (2015) 78:11:2666 | ||||
IC50 | 6.11999989 | |||||
KCNT2
Potassium channel subfamily T member 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.85000038 | |||||
EC50 | 8.85 | ACTIVATOR | ||||
TRPM4
Transient receptor potential cation channel subfamily M member 4
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.5999999 | |||||
IC50 | 5.55 | |||||
AKR1C1
Aldo-keto reductase family 1 member C1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.01 | None, (2016) None:None:None | ||||
TRPA1
Transient receptor potential cation channel subfamily A member 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 3.8 | |||||
TRPM5
Transient receptor potential cation channel subfamily M member 5
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 4.61999989 | |||||
PTGS1
Prostaglandin G/H synthase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 5.52 | INHIBITOR | ||||