Pharos: flufenamic acid

Target Activities

AKR1C3

Tchem

Aldo-keto reductase family 1 member C3

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.3	J. Med. Chem., (2012) 55:5:2311	22263837

IC50	7.29	Bioorg. Med. Chem. Lett., (2011) 21:5:1464	21277203

IC50	7.29	None, (2016) None:None:None

IC50	6.39	J. Med. Chem., (2012) 55:17:7746	22877157

IC50	6.39	Eur. J. Med. Chem., (2013) 62:None:738	23454516

IC50	6.36	Eur J Med Chem, (2017) 139:None:936	28881288

IC50	6.36	Eur J Med Chem, (2018) 150:None:930	29602039

AKR1C2

Tchem

Aldo-keto reductase family 1 member C2

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.43	Bioorg. Med. Chem. Lett., (2011) 21:5:1464	21277203

IC50	6.43	J. Med. Chem., (2012) 55:5:2311	22263837

IC50	6.43	None, (2016) None:None:None

IC50	6.28	Eur J Med Chem, (2017) 139:None:936	28881288

IC50	6.28	Eur J Med Chem, (2018) 150:None:930	29602039

IC50	6.2	None, (2016) None:None:None

PTGS2

Tclin

Prostaglandin G/H synthase 2

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		J. Med. Chem., (2012) 55:5:2311	22263837

IC50	7.8		None, (2016) None:None:None

IC50	7.7		Bioorg. Med. Chem. Lett., (2012) 22:10:3492	22507964

IC50	6.93	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL23588

TRPA1

Tclin

Transient receptor potential cation channel subfamily A member 1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	3.8		19888597

EC50	5.16	Eur J Med Chem, (2019) 170:None:141	30878828

EC50	5.16	Eur J Med Chem, (2019) 170:None:141	30878828

AKR1B10

Tchem

Aldo-keto reductase family 1 member B10

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.12	J. Med. Chem., (2015) 58:5:2047	25375908

IC50	6.12	J. Nat. Prod., (2015) 78:11:2666	26529431

IC50	6.11999989	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL23588

NAPRT

Tchem

Nicotinate phosphoribosyltransferase

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference
Ki	11	None, None:None:None

Ki	11

Ki	11	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL23588

KCNT2

Tchem

Potassium channel subfamily T member 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.85000038			20176855 22851714

EC50	8.85	ACTIVATOR	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2447

TRPM4

Tchem

Transient receptor potential cation channel subfamily M member 4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	5.5999999		15670874

IC50	5.55	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL23588

TRPM5

Tchem

Transient receptor potential cation channel subfamily M member 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	4.61999989

AKR1C1

Tchem

Aldo-keto reductase family 1 member C1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.01		None, (2016) None:None:None

PTGS1

Tclin

Prostaglandin G/H synthase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.52	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL23588