flecainide
Ligand Summary
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
UNII: K94FTS1806
PubChem: 3356
Guide to Pharmacology: 2560
ChEMBL: CHEMBL652
DrugCentral: 1176
LyCHI: WH3Z9G1L6VMT
Target Activities
KCNH2
Potassium voltage-gated channel subfamily H member 2
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.41 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 5.41 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 5.41 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 5.41 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
SCN5A
Sodium channel protein type 5 subunit alpha
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.19 | J. Med. Chem., (2007) 50:12:2818 | ||||
IC50 | 5.19 | BLOCKER | ||||
KCNA1
Potassium voltage-gated channel subfamily A member 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 3.7 | |||||
KCNA2
Potassium voltage-gated channel subfamily A member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 3.7 | |||||
KCNA5
Potassium voltage-gated channel subfamily A member 5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
4 | ||||||
KCNA7
Potassium voltage-gated channel subfamily A member 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
5.1 | ||||||
KCNC1
Potassium voltage-gated channel subfamily C member 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
4 | ||||||