Pharos : Ligand Details - fingolimod

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A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: 3QN8BYN5QF

PubChem: 107970

Guide to Pharmacology: 2407

ChEMBL: CHEMBL314854

DrugCentral: 4167

LyCHI: 7TJCA8256R3B

Target Activities

S1PR1

Tclin

Sphingosine 1-phosphate receptor 1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.14		Bioorg. Med. Chem. Lett., (2016) 26:2:466	26687487

EC50	9.52		Bioorg. Med. Chem. Lett., (2013) 23:23:6377	24125884

IC50	6.07999992			15615513

EC50	9.52	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314854

S1PR5

Tclin

Sphingosine 1-phosphate receptor 5

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	9.52		Bioorg. Med. Chem. Lett., (2013) 23:23:6377	24125884

IC50	5.67999983			15615513

EC50	9.52	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314854

S1PR3

Tclin

Sphingosine 1-phosphate receptor 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.52		Bioorg. Med. Chem. Lett., (2013) 23:23:6377	24125884

EC50	8.52	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314854

S1PR4

Tclin

Sphingosine 1-phosphate receptor 4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	9.52		Bioorg. Med. Chem. Lett., (2013) 23:23:6377	24125884

EC50	9.52	AGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314854

TRPM7

Tchem

Transient receptor potential cation channel subfamily M member 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.14			23145923