fingolimod
A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS.
Ligand Summary
UNII: 3QN8BYN5QF
PubChem: 107970
Guide to Pharmacology: 2407
ChEMBL: CHEMBL314854
DrugCentral: 4167
LyCHI: 7TJCA8256R3B
Target Activities
S1PR1
Sphingosine 1-phosphate receptor 1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.08 | |||||
EC50 | 9.52 | Bioorg. Med. Chem. Lett., (2013) 23:23:6377 | ||||
EC50 | 8.7 | Bioorg. Med. Chem. Lett., (2012) 22:1:527 | ||||
EC50 | 8.14 | Bioorg. Med. Chem. Lett., (2016) 26:2:466 | ||||
EC50 | 9.52 | AGONIST | ||||
S1PR5
Sphingosine 1-phosphate receptor 5
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.68 | |||||
EC50 | 9.52 | Bioorg. Med. Chem. Lett., (2013) 23:23:6377 | ||||
EC50 | 9.52 | AGONIST | ||||
S1PR4
Sphingosine 1-phosphate receptor 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 9.52 | Bioorg. Med. Chem. Lett., (2013) 23:23:6377 | ||||
EC50 | 9.52 | AGONIST | ||||
S1PR3
Sphingosine 1-phosphate receptor 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.52 | Bioorg. Med. Chem. Lett., (2013) 23:23:6377 | ||||
EC50 | 8.52 | AGONIST | ||||
TRPM7
Transient receptor potential cation channel subfamily M member 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.14 | |||||