Pharos : Ligand Details - finasteride

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An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 57GNO57U7G

PubChem: 57363

Guide to Pharmacology: 6818

ChEMBL: CHEMBL710

DrugCentral: 1171

LyCHI: NMC5ZNMQ7URT

Target Activities

SRD5A2

Tclin

3-oxo-5-alpha-steroid 4-dehydrogenase 2

30 Activities

Items per page:

1 – 10 of 30

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.84000015			3783591

IC50	9.74		J. Med. Chem., (1993) 36:26:4313	8277514

IC50	9.74		J. Med. Chem., (1997) 40:9:1293	9135028

IC50	9.74		J. Med. Chem., (1994) 37:15:2352	8057283

IC50	9.74		J. Med. Chem., (1995) 38:14:2621	7629802

IC50	9.74		J Med Chem, (2018) 61:14:5822	29400967

IC50	8.92		Bioorg. Med. Chem. Lett., (1998) 8:20:2871	9873639

IC50	8.92		J Med Chem, (2018) 61:14:5822	29400967

Ki	8.7		Bioorg. Med. Chem. Lett., (1994) 4:19:2327

IC50	8.7		J. Med. Chem., (2005) 48:8:2972	15828836

SRD5A1

Tclin

3-oxo-5-alpha-steroid 4-dehydrogenase 1

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.58		J. Med. Chem., (1995) 38:7:1158	7707319

IC50	7.4		J. Med. Chem., (2000) 43:22:4266	11063622

IC50	7.39		J. Med. Chem., (2002) 45:16:3406	12139451

IC50	7.28		J. Med. Chem., (1995) 38:17:3189	7650670

IC50	7.28		J. Med. Chem., (1994) 37:23:3871	7966146

IC50	7.28		J Med Chem, (2018) 61:14:5822	29400967

IC50	7.22		J. Med. Chem., (2005) 48:8:2972	15828836

IC50	7.21		J. Med. Chem., (1993) 36:3:421	8381185

Ki	7		Bioorg. Med. Chem. Lett., (1994) 4:19:2327

IC50	6.82		J. Med. Chem., (1993) 36:26:4313	8277514

CYP2C19

Tchem

Cytochrome P450 2C19

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		None, None:None:None