You are using an outdated browser. Please upgrade your browser to improve your experience.

fedratinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Fedratinib is an oral kinase inhibitor with activity against wild type and mutationally activated Janus Associated Kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3). Fedratinib is a JAK2-selective inhibitor with higher inhibitory activity for JAK2 over family members JAK1, JAK3 and TYK2. Abnormal activation of JAK2 is associated with myeloproliferative neoplasms (MPNs), including myelofibrosis and polycythemia vera.
Synonyms & Links
Guide to Pharmacology: 5716
DrugCentral: 5347
LyCHI:  GUJY5FTRMBSB


Target Activities