Pharos : Ligand Details - fadrozole

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A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: H3988M64PU

PubChem: 59694

PubChem: 59693

Guide to Pharmacology: 8311

ChEMBL: CHEMBL468419

ChEMBL: CHEMBL9298

DrugCentral: 1126

LyCHI: MSK42XHU1T6H

Target Activities

Explore Associated and Predicted Targets

CYP19A1

Tclin

Aromatase

38 Activities

Items per page:

1 – 10 of 38

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.35			1825337

IC50	10.52		J. Med. Chem., (1991) 34:2:725	1825337

Ki	10.3		Bioorg. Med. Chem., (2012) 20:7:2427	22386564

Ki	9.22		Bioorg. Med. Chem. Lett., (1998) 8:9:1041	9871704

Ki	8.82		J. Med. Chem., (1990) 33:11:2933	2231592

Ki	8.82		J. Med. Chem., (1991) 34:2:725	1825337

IC50	8.52		Bioorg. Med. Chem., (2012) 20:7:2427	22386564

IC50	8.35		J. Med. Chem., (2014) 57:12:5011	24422519

IC50	8.34		J. Med. Chem., (1991) 34:2:725	1825337

IC50	8.3		J. Med. Chem., (2005) 48:6:1796	15771425

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.1			19622340

IC50	9.1		J. Med. Chem., (2012) 55:16:7080	22861193

IC50	9.1		J. Med. Chem., (2013) 56:2:460	23281812

IC50	9.1		J. Med. Chem., (2013) 56:4:1723	23363058

IC50	9.1		J. Med. Chem., (2013) 56:15:6101	23859149

IC50	9.1		J. Med. Chem., (2014) 57:12:5179	24899257

IC50	9.1		Eur. J. Med. Chem., (2015) 89:None:597	25462268

IC50	9.1		Eur. J. Med. Chem., (2015) 90:None:788	25528333

IC50	9.1		J. Med. Chem., (2015) 58:5:2530	25711516

IC50	9		J. Med. Chem., (2005) 48:6:1796	15771425

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

23 Activities

Items per page:

1 – 10 of 23

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.66			19622340

IC50	8.2		J. Med. Chem., (2012) 55:16:7080	22861193

IC50	8.2		J. Med. Chem., (2013) 56:2:460	23281812

IC50	8.2		J. Med. Chem., (2013) 56:4:1723	23363058

IC50	8.2		J. Med. Chem., (2013) 56:15:6101	23859149

IC50	8.2		J. Med. Chem., (2014) 57:12:5179	24899257

IC50	8.2		Eur. J. Med. Chem., (2015) 89:None:597	25462268

IC50	8.2		Eur. J. Med. Chem., (2015) 90:None:788	25528333

IC50	8.2		J. Med. Chem., (2015) 58:5:2530	25711516

IC50	8.05		None, (2016) None:None:None