Pharos : Ligand Details - fadrozole

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A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: H3988M64PU

PubChem: 59693

PubChem: 59694

Guide to Pharmacology: 8311

ChEMBL: CHEMBL9298

ChEMBL: CHEMBL468419

DrugCentral: 1126

LyCHI: MSK42XHU1T6H

Target Activities

CYP19A1

Tclin

Aromatase

36 Activities

Items per page:

1 – 10 of 36

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.7		Bioorg. Med. Chem. Lett., (1998) 8:9:1041	9871704

IC50	7.28		J. Med. Chem., (2011) 54:6:1613	21341743

IC50	7.28		J. Med. Chem., (2001) 44:5:672	11262078

IC50	7.28		J. Med. Chem., (2007) 50:15:3420	17585752

IC50	7.28		J. Med. Chem., (2012) 55:16:7080	22861193

IC50	7.28		J. Med. Chem., (2006) 49:15:4777	16854084

IC50	7.28		J. Med. Chem., (2010) 53:14:5347	20568782

IC50	7.3		Bioorg. Med. Chem., (2008) 16:18:8349	18782670

IC50	7.39		J. Med. Chem., (2012) 55:14:6629	22788843

IC50	7.39		J. Med. Chem., (2013) 56:4:1723	23363058

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.73		None, (2016) None:None:None

IC50	8.22		J. Med. Chem., (2015) 58:20:8054	26403853

IC50	9		J. Med. Chem., (2011) 54:6:1613	21341743

IC50	9		J. Med. Chem., (2005) 48:5:1563	15743198

IC50	9		J. Med. Chem., (2005) 48:6:1796	15771425

IC50	9		J. Med. Chem., (2005) 48:21:6632	16220979

IC50	9		J. Med. Chem., (2006) 49:7:2222	16570918

IC50	9		J. Med. Chem., (2008) 51:16:5064	18672861

IC50	9		J. Med. Chem., (2008) 51:19:6138	18763754

IC50	9		None, (2016) None:None:None

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

23 Activities

Items per page:

1 – 10 of 23

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.55		None, (2016) None:None:None

IC50	8		J. Med. Chem., (2011) 54:6:1613	21341743

IC50	8		J. Med. Chem., (2005) 48:5:1563	15743198

IC50	8		J. Med. Chem., (2005) 48:21:6632	16220979

IC50	8		J. Med. Chem., (2006) 49:7:2222	16570918

IC50	8		J. Med. Chem., (2008) 51:16:5064	18672861

IC50	8		J. Med. Chem., (2008) 51:19:6138	18763754

IC50	8		None, (2016) None:None:None

IC50	8		None, (2016) None:None:None

IC50	8		J. Med. Chem., (2011) 54:7:2307	21384875