fadrozole
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
Ligand Summary
UNII: H3988M64PU
PubChem: 59694
PubChem: 59693
Guide to Pharmacology: 8311
ChEMBL: CHEMBL468419
ChEMBL: CHEMBL9298
DrugCentral: 1126
LyCHI: MSK42XHU1T6H
Target Activities
CYP19A1
Aromatase
38 Activities
Items per page:
1 – 10 of 38
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.35 | |||||
IC50 | 10.52 | J. Med. Chem., (1991) 34:2:725 | ||||
Ki | 10.3 | Bioorg. Med. Chem., (2012) 20:7:2427 | ||||
Ki | 9.22 | Bioorg. Med. Chem. Lett., (1998) 8:9:1041 | ||||
Ki | 8.82 | J. Med. Chem., (1990) 33:11:2933 | ||||
Ki | 8.82 | J. Med. Chem., (1991) 34:2:725 | ||||
IC50 | 8.52 | Bioorg. Med. Chem., (2012) 20:7:2427 | ||||
IC50 | 8.35 | J. Med. Chem., (2014) 57:12:5011 | ||||
IC50 | 8.34 | J. Med. Chem., (1991) 34:2:725 | ||||
IC50 | 8.3 | J. Med. Chem., (2005) 48:6:1796 | ||||
CYP11B2
Cytochrome P450 11B2, mitochondrial
25 Activities
Items per page:
1 – 10 of 25
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 9.1 | |||||
IC50 | 9.1 | J. Med. Chem., (2012) 55:16:7080 | ||||
IC50 | 9.1 | J. Med. Chem., (2013) 56:2:460 | ||||
IC50 | 9.1 | J. Med. Chem., (2013) 56:4:1723 | ||||
IC50 | 9.1 | J. Med. Chem., (2013) 56:15:6101 | ||||
IC50 | 9.1 | J. Med. Chem., (2014) 57:12:5179 | ||||
IC50 | 9.1 | Eur. J. Med. Chem., (2015) 89:None:597 | ||||
IC50 | 9.1 | Eur. J. Med. Chem., (2015) 90:None:788 | ||||
IC50 | 9.1 | J. Med. Chem., (2015) 58:5:2530 | ||||
IC50 | 9 | J. Med. Chem., (2005) 48:6:1796 | ||||
CYP11B1
Cytochrome P450 11B1, mitochondrial
23 Activities
Items per page:
1 – 10 of 23
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.66 | |||||
IC50 | 8.2 | J. Med. Chem., (2012) 55:16:7080 | ||||
IC50 | 8.2 | J. Med. Chem., (2013) 56:2:460 | ||||
IC50 | 8.2 | J. Med. Chem., (2013) 56:4:1723 | ||||
IC50 | 8.2 | J. Med. Chem., (2013) 56:15:6101 | ||||
IC50 | 8.2 | J. Med. Chem., (2014) 57:12:5179 | ||||
IC50 | 8.2 | Eur. J. Med. Chem., (2015) 89:None:597 | ||||
IC50 | 8.2 | Eur. J. Med. Chem., (2015) 90:None:788 | ||||
IC50 | 8.2 | J. Med. Chem., (2015) 58:5:2530 | ||||
IC50 | 8.05 | None, (2016) None:None:None | ||||