everolimus
A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.
Ligand Summary
UNII: 9HW64Q8G6G
PubChem: 6442177
Guide to Pharmacology: 5889
ChEMBL: CHEMBL1908360
DrugCentral: 1118
LyCHI: 3XY9KTG65JPM
Target Activities
MTOR
Serine/threonine-protein kinase mTOR
3 Activities
FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.26 | INHIBITOR | ||||