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etoposide

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Synonyms & Links
Guide to Pharmacology: 6815
DrugCentral: 1112
LyCHI:  97NMMX2S4TLG


Target Activities