etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Ligand Summary
UNII: 6PLQ3CP4P3
PubChem: 36462
Guide to Pharmacology: 6815
ChEMBL: CHEMBL44657
DrugCentral: 1112
LyCHI: 97NMMX2S4TLG
Target Activities
TOP2A
DNA topoisomerase 2-alpha
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.30000019 | |||||
IC50 | 7.3 | INHIBITOR | ||||
TOP2B
DNA topoisomerase 2-beta
2 Activities
NCOA3
Nuclear receptor coactivator 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.43 | None, None:None:None | ||||