etomidate
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Ligand Summary
UNII: Z22628B598
PubChem: 667484
ChEMBL: CHEMBL681
DrugCentral: 1109
LyCHI: VQGGC11AF8PL
Target Activities
CYP11B2
Cytochrome P450 11B2, mitochondrial
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 10 | ACS Med. Chem. Lett., (2011) 2:1:2 | ||||
IC50 | 10 | ACS Med. Chem. Lett., (2011) 2:8:559 | ||||
IC50 | 8.77 | J. Med. Chem., (2010) 53:4:1712 | ||||
IC50 | 8.77 | J. Med. Chem., (2014) 57:12:5011 | ||||
IC50 | 10 | |||||
CYP11B1
Cytochrome P450 11B1, mitochondrial
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.3 | J. Med. Chem., (2010) 53:4:1712 | ||||
IC50 | 9.3 | ACS Med. Chem. Lett., (2011) 2:1:2 | ||||
IC50 | 9.3 | ACS Med. Chem. Lett., (2011) 2:8:559 | ||||
IC50 | 9.3 | J. Med. Chem., (2014) 57:12:5011 | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.46 | POSITIVE MODULATOR | ||||
GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.46 | POSITIVE MODULATOR | ||||
GABRB2
Gamma-aminobutyric acid receptor subunit beta-2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.46 | POSITIVE MODULATOR | ||||