estrone
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
Ligand Summary
UNII: 2DI9HA706A
PubChem: 5870
Guide to Pharmacology: 2818
ChEMBL: CHEMBL1405
DrugCentral: 3188
LyCHI: M3SWMTZ32PK9
Target Activities
ESR1
Estrogen receptor
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.02 | Bioorg. Med. Chem. Lett., (2009) 19:23:6740 | ||||
IC50 | 7.54 | J. Med. Chem., (2006) 49:8:2440 | ||||
IC50 | 8.12 | None, None:None:None | ||||
EC50 | 8.15 | J. Med. Chem., (2009) 52:21:6660 | ||||
Ki | 8.66 | None, None:None:None | ||||
EC50 | 9.15 | J. Med. Chem., (2002) 45:7:1399 | ||||
- | 8.5 | |||||
EC50 | 9.15 | AGONIST | ||||
HSD17B1
Estradiol 17-beta-dehydrogenase 1
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.09 | Eur. J. Med. Chem., (2008) 43:11:2298 | ||||
IC50 | 6.22 | Eur. J. Med. Chem., (2008) 43:11:2298 | ||||
IC50 | 6.66 | Bioorg. Med. Chem., (2008) 16:4:1849 | ||||
IC50 | 6.96 | Bioorg. Med. Chem. Lett., (2009) 19:23:6740 | ||||
Ki | 8.52 | Eur. J. Med. Chem., (2008) 43:11:2298 | ||||
Ki | 8.52 | |||||
ESR2
Estrogen receptor beta
4 Activities
SHBG
Sex hormone-binding globulin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.18 | J. Med. Chem., (2008) 51:7:2047 | ||||
Kd | 8.18 | |||||