estriol
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Ligand Summary
UNII: FB33469R8E
PubChem: 5756
Guide to Pharmacology: 2821
ChEMBL: CHEMBL193482
DrugCentral: 3187
LyCHI: 8SYMQZFWNLLN
Target Activities
ESR1
Estrogen receptor
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 8.67 | |||||
Ki | 9.32 | None, None:None:None | ||||
IC50 | 8.77 | None, None:None:None | ||||
EC50 | 8.7 | MedChemComm, (2013) 4:11:1439 | ||||
Ki | 8.67 | AGONIST | ||||
ESR2
Estrogen receptor beta
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8.4 | ||||||
EC50 | 9.9 | MedChemComm, (2013) 4:11:1439 | ||||
SHBG
Sex hormone-binding globulin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.63 | J. Med. Chem., (2008) 51:7:2047 | ||||
Kd | 6.63 | |||||