Pharos : Ligand Details

Target Activities

Items per page:

1 – 8 of 8

ESR1

Tclin

Estrogen receptor

92 Activities

Items per page:

1 – 10 of 92

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7	J. Med. Chem., (2003) 46:19:4032	12954056

IC50	7.34	Bioorg. Med. Chem., (2010) 18:21:7675	20875743

IC50	7.34	J. Med. Chem., (2006) 49:18:5404	16942012

IC50	7.55	J. Med. Chem., (2005) 48:2:364	15658851

IC50	7.55	J. Med. Chem., (2003) 46:14:2945	12825935

EC50	7.62	J. Med. Chem., (2002) 45:7:1399	11906280

IC50	7.75	J. Nat. Prod., (2011) 74:5:937	21510635

IC50	7.9	Bioorg. Med. Chem. Lett., (2009) 19:23:6740	19836949

Ki	7.92	Bioorg. Med. Chem. Lett., (2007) 17:11:3212	17379515

IC50	7.96	Bioorg. Med. Chem. Lett., (2004) 14:9:2327	15081034

ESR2

Tclin

Estrogen receptor beta

76 Activities

Items per page:

1 – 10 of 76

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7	J. Med. Chem., (2003) 46:19:4032	12954056

IC50	7.62	J. Med. Chem., (2005) 48:2:364	15658851

EC50	7.62	J. Med. Chem., (2002) 45:7:1399	11906280

IC50	7.62	J. Med. Chem., (2003) 46:14:2945	12825935

IC50	7.72	Bioorg. Med. Chem. Lett., (2004) 14:9:2327	15081034

IC50	7.78	J. Med. Chem., (2007) 50:18:4471	17696335

IC50	7.95	J. Med. Chem., (2010) 53:10:4290	20408532

IC50	7.96	J. Med. Chem., (2006) 49:8:2440	16610787

EC50	7.96	J. Nat. Prod., (2009) 72:11:1944	19863083

IC50	8.25	J. Med. Chem., (2014) 57:22:9370	25369367

ESRRB

Tchem

Steroid hormone receptor ERR2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.06	J. Med. Chem., (2013) 56:7:2779	23448346

IC50	8.49	Bioorg. Med. Chem. Lett., (2007) 17:14:4053	17482813

IC50	8.49	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

SHBG

Tchem

Sex hormone-binding globulin

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.3	J. Med. Chem., (2006) 49:25:7466	17149875

Kd	8.83	J. Med. Chem., (2008) 51:7:2047	18330978

Kd	8.83	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

GPER1

Tchem

G-protein coupled estrogen receptor 1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.24	J. Med. Chem., (2013) 56:18:7161	23672690

Ki	8.24	Nat. Chem. Biol., (2006) 2:4:207	16520733

Ki	8.57	MedChemComm, (2016) 7:3:439

AR

Tclin

Androgen receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.58	Bioorg. Med. Chem. Lett., (2007) 17:22:6295	17890084

IC50	7.72	Bioorg. Med. Chem. Lett., (2006) 16:4:834	16309907

IC50	7.72	Bioorg. Med. Chem. Lett., (2007) 17:10:2944	17448656

ESRRA

Tchem

Steroid hormone receptor ERR1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.22	J. Med. Chem., (2013) 56:7:2779	23448346

IC50	8.44	Bioorg. Med. Chem. Lett., (2007) 17:14:4053	17482813

IC50	8.44	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

KCNMA1

Tclin

Calcium-activated potassium channel subunit alpha-1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.6			10489376