Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

ESR1

Tclin

Estrogen receptor

133 Activities

Items per page:

1 – 10 of 133

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	9.82		9048584

EC50	11	Bioorg. Med. Chem. Lett., (2005) 15:24:5562	16219463

EC50	10.74	J. Med. Chem., (2001) 44:24:4230	11708925

EC50	10.72	J. Med. Chem., (2005) 48:19:5989	16162002

EC50	10.7	J. Med. Chem., (2002) 45:7:1399	11906280

EC50	10.62	Bioorg. Med. Chem. Lett., (2014) 24:22:5265	25305688

EC50	10.52	J Nat Prod, (2018) 81:4:966	29641206

EC50	10.34	Bioorg. Med. Chem. Lett., (2011) 21:19:5680	21885279

EC50	10.33	J. Nat. Prod., (2004) 67:11:1829	15568770

EC50	10.3	Eur. J. Med. Chem., (2012) 54:None:188	22647217

ESR2

Tclin

Estrogen receptor beta

114 Activities

Items per page:

1 – 10 of 114

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	9.34		9048584

EC50	11	J. Med. Chem., (2012) 55:22:9607	23043242

Ki	10.82	None, (2015) None:None:None

Ki	10.82	None, (2015) None:None:None

EC50	10.7	Bioorg Med Chem, (2019) 27:10:2075	30967304

EC50	10.66	Eur J Med Chem, (2018) 157:None:791	30144697

EC50	10.66	J Med Chem, (2018) 61:11:4720	29741891

EC50	10.52	J Nat Prod, (2018) 81:4:966	29641206

EC50	10.52	Bioorg Med Chem, (2019) 27:10:2075	30967304

EC50	10.44	Eur. J. Med. Chem., (2012) 54:None:188	22647217

GPER1

Tchem

G-protein coupled estrogen receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	9.52	Nat. Chem. Biol., (2006) 2:4:207	16520733

EC50	9.52	J. Med. Chem., (2013) 56:18:7161	23672690

Ki	8.57	MedChemComm, (2016) 7:3:439

Ki	8.24	Nat. Chem. Biol., (2006) 2:4:207	16520733

Ki	8.24	J. Med. Chem., (2013) 56:18:7161	23672690

ESRRA

Tchem

Steroid hormone receptor ERR1

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.44	Bioorg. Med. Chem. Lett., (2007) 17:14:4053	17482813

EC50	8.23	J. Med. Chem., (2011) 54:3:788	21218783

IC50	8.22	J. Med. Chem., (2013) 56:7:2779	23448346

IC50	8.44	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

ESRRB

Tchem

Steroid hormone receptor ERR2

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.49	Bioorg. Med. Chem. Lett., (2007) 17:14:4053	17482813

EC50	8.34	J. Med. Chem., (2011) 54:3:788	21218783

IC50	8.06	J. Med. Chem., (2013) 56:7:2779	23448346

IC50	8.49	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

SHBG

Tchem

Sex hormone-binding globulin

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.83	J. Med. Chem., (2008) 51:7:2047	18330978

IC50	7.3	J. Med. Chem., (2006) 49:25:7466	17149875

Kd	8.83	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL135

AR

Tclin

Androgen receptor

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.72	Bioorg. Med. Chem. Lett., (2006) 16:4:834	16309907

IC50	7.72	Bioorg. Med. Chem. Lett., (2007) 17:10:2944	17448656

IC50	7.58	Bioorg. Med. Chem. Lett., (2007) 17:22:6295	17890084

AOX1

Tchem

Aldehyde oxidase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.1	J. Med. Chem., (2010) 53:24:8441	20853847

Ki	6.06	Drug Metab. Dispos., (2013) 41:1:24	22996261

KCNMA1

Tclin

Calcium-activated potassium channel subunit alpha-1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.6			10489376