estradiol
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Ligand Summary
UNII: 4TI98Z838E
PubChem: 5757
Guide to Pharmacology: 1013
ChEMBL: CHEMBL135
DrugCentral: 1057
LyCHI: M3TNLZD5Z8Y9
Target Activities
ESR1
Estrogen receptor
133 Activities
Items per page:
1 – 10 of 133
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 9.82 | |||||
EC50 | 11 | Bioorg. Med. Chem. Lett., (2005) 15:24:5562 | ||||
EC50 | 10.74 | J. Med. Chem., (2001) 44:24:4230 | ||||
EC50 | 10.72 | J. Med. Chem., (2005) 48:19:5989 | ||||
EC50 | 10.7 | J. Med. Chem., (2002) 45:7:1399 | ||||
EC50 | 10.62 | Bioorg. Med. Chem. Lett., (2014) 24:22:5265 | ||||
EC50 | 10.52 | J Nat Prod, (2018) 81:4:966 | ||||
EC50 | 10.34 | Bioorg. Med. Chem. Lett., (2011) 21:19:5680 | ||||
EC50 | 10.33 | J. Nat. Prod., (2004) 67:11:1829 | ||||
EC50 | 10.3 | Eur. J. Med. Chem., (2012) 54:None:188 | ||||
ESR2
Estrogen receptor beta
114 Activities
Items per page:
1 – 10 of 114
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
9.34 | ||||||
EC50 | 11 | J. Med. Chem., (2012) 55:22:9607 | ||||
Ki | 10.82 | None, (2015) None:None:None | ||||
Ki | 10.82 | None, (2015) None:None:None | ||||
EC50 | 10.7 | Bioorg Med Chem, (2019) 27:10:2075 | ||||
EC50 | 10.66 | Eur J Med Chem, (2018) 157:None:791 | ||||
EC50 | 10.66 | J Med Chem, (2018) 61:11:4720 | ||||
EC50 | 10.52 | J Nat Prod, (2018) 81:4:966 | ||||
EC50 | 10.52 | Bioorg Med Chem, (2019) 27:10:2075 | ||||
EC50 | 10.44 | Eur. J. Med. Chem., (2012) 54:None:188 | ||||
GPER1
G-protein coupled estrogen receptor 1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 9.52 | Nat. Chem. Biol., (2006) 2:4:207 | ||||
EC50 | 9.52 | J. Med. Chem., (2013) 56:18:7161 | ||||
Ki | 8.57 | MedChemComm, (2016) 7:3:439 | ||||
Ki | 8.24 | Nat. Chem. Biol., (2006) 2:4:207 | ||||
Ki | 8.24 | J. Med. Chem., (2013) 56:18:7161 | ||||
ESRRA
Steroid hormone receptor ERR1
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.44 | Bioorg. Med. Chem. Lett., (2007) 17:14:4053 | ||||
EC50 | 8.23 | J. Med. Chem., (2011) 54:3:788 | ||||
IC50 | 8.22 | J. Med. Chem., (2013) 56:7:2779 | ||||
IC50 | 8.44 | |||||
ESRRB
Steroid hormone receptor ERR2
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.49 | Bioorg. Med. Chem. Lett., (2007) 17:14:4053 | ||||
EC50 | 8.34 | J. Med. Chem., (2011) 54:3:788 | ||||
IC50 | 8.06 | J. Med. Chem., (2013) 56:7:2779 | ||||
IC50 | 8.49 | |||||
SHBG
Sex hormone-binding globulin
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.83 | J. Med. Chem., (2008) 51:7:2047 | ||||
IC50 | 7.3 | J. Med. Chem., (2006) 49:25:7466 | ||||
Kd | 8.83 | |||||
AR
Androgen receptor
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.72 | Bioorg. Med. Chem. Lett., (2006) 16:4:834 | ||||
IC50 | 7.72 | Bioorg. Med. Chem. Lett., (2007) 17:10:2944 | ||||
IC50 | 7.58 | Bioorg. Med. Chem. Lett., (2007) 17:22:6295 | ||||
AOX1
Aldehyde oxidase
2 Activities
KCNMA1
Calcium-activated potassium channel subunit alpha-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
5.6 | ||||||