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Ligand Summary
Ligand Structure
Rendered image for the query structure
SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. Ertugliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, ertugliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion.
Synonyms & Links
Guide to Pharmacology: 8376
DrugCentral: 5270

Target Activities