ergotamine
A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
Ligand Summary
UNII: PR834Q503T
PubChem: 8223
Guide to Pharmacology: 149
ChEMBL: CHEMBL442
DrugCentral: 1043
LyCHI: PLGGTZHS2G1M
Target Activities
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10
1 – 10 of 16
HTR1D
5-hydroxytryptamine receptor 1D
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.22 | Bioorg. Med. Chem., (2011) 19:19:5756 | ||||
Ki | 8.37 | Bioorg. Med. Chem. Lett., (2011) 21:22:6714 | ||||
Ki | 8.58 | Bioorg. Med. Chem. Lett., (2014) 24:2:576 | ||||
Ki | 8.66 | Bioorg. Med. Chem. Lett., (2014) 24:2:576 | ||||
Ki | 9.1 | J. Med. Chem., (2000) 43:5:1011 | ||||
Ki | 9.10000038 | |||||
Ki | 9.1 | AGONIST | ||||
HTR5A
5-hydroxytryptamine receptor 5A
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.4 | J. Med. Chem., (2003) 46:14:2795 | ||||
Ki | 7.66 | J. Med. Chem., (2000) 43:5:1011 | ||||
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2014) 24:2:576 | ||||
Ki | 7.81 | Bioorg. Med. Chem. Lett., (2014) 24:2:576 | ||||
Ki | 7.85 | Bioorg. Med. Chem., (2011) 19:19:5756 | ||||
8.2 | ||||||
Ki | 7.85 | |||||
HTR2C
5-hydroxytryptamine receptor 2C
4 Activities
HTR2A
5-hydroxytryptamine receptor 2A
4 Activities
HTR6
5-hydroxytryptamine receptor 6
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.69 | None, None:None:None | ||||
Ki | 9.02 | None, None:None:None | ||||
Ki | 8.6 | AGONIST | ||||
HTR1B
5-hydroxytryptamine receptor 1B
3 Activities
ADRA1D
Alpha-1D adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.31 | None, None:None:None | ||||
Ki | 7.62 | None, None:None:None | ||||
DRD2
D(2) dopamine receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.37 | None, None:None:None | ||||
Ki | 8.84 | None, None:None:None | ||||
ADRA2A
Alpha-2A adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.67 | None, None:None:None | ||||
Ki | 9.1 | None, None:None:None | ||||
ADRA2C
Alpha-2C adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.92 | None, None:None:None | ||||
Ki | 8.74 | None, None:None:None | ||||