Pharos : Ligand Details - epalrestat

You are using an outdated browser. Please upgrade your browser to improve your experience.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 424DV0807X

PubChem: 1549120

ChEMBL: CHEMBL56337

DrugCentral: 1021

LyCHI: TW9BA8K15VZA

Target Activities

Explore Associated and Predicted Targets

AKR1B1

Tclin

Aldose reductase

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2003) 46:3:417	12540241

IC50	7.68		Bioorg. Med. Chem., (2010) 18:7:2485	20304656

IC50	7.07		Eur J Med Chem, (2017) 125:None:965	27769036

IC50	7.03		Bioorg Med Chem Lett, (2017) 27:18:4482	28802633

IC50	7		Bioorg. Med. Chem., (2012) 20:1:356	22104435

IC50	6.99		Bioorg Med Chem Lett, (2018) 28:23-24:3712	30342956

IC50	6.96		Bioorg Med Chem Lett, (2020) 30:2:126815	31744675

IC50	6.96		Bioorg Med Chem Lett, (2020) 30:2:126815	31744675

IC50	6.82		Bioorg Med Chem Lett, (2020) 30:2:126815	31744675

IC50	6.21		Eur J Med Chem, (2019) 168:None:154	30818176

AKR1B10

Tchem

Aldo-keto reductase family 1 member B10

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.45		Bioorg Med Chem Lett, (2020) 30:2:126815	31744675

IC50	7.41		Bioorg Med Chem Lett, (2020) 30:2:126815	31744675

IC50	6.48		Bioorg. Med. Chem., (2010) 18:7:2485	20304656

IC50	6.48		Bioorg. Med. Chem., (2012) 20:1:356	22104435

IC50	6.48		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL56337