enalaprilat
The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.
Ligand Summary
UNII: Q508Q118JM
PubChem: 5462501
Guide to Pharmacology: 6332
ChEMBL: CHEMBL577
DrugCentral: 1006
LyCHI: NVHP63K624ML
Target Activities
ACE
Angiotensin-converting enzyme
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.5 | |||||
IC50 | 8.92 | J. Med. Chem., (1985) 28:4:434 | ||||
IC50 | 8.92 | J. Med. Chem., (1986) 29:2:251 | ||||
IC50 | 8.92 | J. Med. Chem., (1993) 36:15:2051 | ||||
IC50 | 8.92 | J. Med. Chem., (2002) 45:26:5609 | ||||
IC50 | 8.92 | J. Med. Chem., (1990) 33:6:1606 | ||||
IC50 | 8.62 | J. Med. Chem., (1986) 29:10:1953 | ||||
IC50 | 8.6 | Bioorg Med Chem Lett, (2017) 27:11:2313 | ||||
IC50 | 8.59 | J. Med. Chem., (1989) 32:7:1600 | ||||
IC50 | 8.54 | J. Med. Chem., (1989) 32:2:289 | ||||