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eluxadoline

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Eluxadoline is a mu-opioid receptor agonist; eluxadoline is also a delta opioid receptor antagonist and a kappa opioid receptor agonist. The binding affinities (Ki) of eluxadoline for the human mu and delta opioid receptors are 1.8 nM and 430 nM, respectively. The binding affinity (Ki) of eluxadoline for the human kappa opioid receptor has not been determined; however, the Ki for guinea pig cerebellum kappa opioid receptor is 55 nM. In animals, eluxadoline interacts with opioid receptors in the gut.
Synonyms & Links
Guide to Pharmacology: 7691
DrugCentral: 5001
LyCHI:  K7W3932HVKSB


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Target Activities