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duvelisib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Duvelisib is an inhibitor of PI3K with inhibitory activity predominantly against PI3K-delta and PI3K-gamma isoforms expressed in normal and malignant B-cells. Duvelisib induced growth inhibition and reduced viability in cell lines derived from malignant B-cells and in primary CLL tumor cells. Duvelisib inhibits several key cell-signaling pathways, including B-cell receptor signaling and CXCR12-mediated chemotaxis of malignant B-cells. Additionally, duvelisib inhibits CXCL12-induced T cell migration and M-CSF and IL-4 driven M2 polarization of macrophages.
Synonyms & Links
Guide to Pharmacology: 7795
DrugCentral: 5296
LyCHI:  GGYZ7HLK7TDA


Target Activities