dutasteride
A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA.
Ligand Summary
UNII: O0J6XJN02I
PubChem: 6918296
ChEMBL: CHEMBL1200969
DrugCentral: 973
LyCHI: 6F6RG1Y37Y7T
Target Activities
SRD5A1
3-oxo-5-alpha-steroid 4-dehydrogenase 1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.4 | J Med Chem, (2018) 61:14:5822 | ||||
IC50 | 8.49 | INHIBITOR | ||||
GLRA1
Glycine receptor subunit alpha-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.48 | J. Med. Chem., (2015) 58:7:2958 | ||||
SRD5A2
3-oxo-5-alpha-steroid 4-dehydrogenase 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.2 | INHIBITOR | ||||