dronabinol
A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.
Ligand Summary
UNII: 7J8897W37S
PubChem: 16078
Guide to Pharmacology: 2424
ChEMBL: CHEMBL465
DrugCentral: 4109
LyCHI: UX411P34XKA9
Target Activities
CNR2
Cannabinoid receptor 2
25 Activities
Items per page:
1 – 10 of 25
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.82 | Bioorg. Med. Chem. Lett., (2008) 18:13:3695 | ||||
Ki | 8.48 | Bioorg. Med. Chem. Lett., (2007) 17:14:3925 | ||||
IC50 | 8.02 | J. Nat. Prod., (2011) 74:10:2313 | ||||
EC50 | 7.91 | Eur. J. Med. Chem., (2014) 85:None:77 | ||||
Ki | 7.62 | Bioorg. Med. Chem. Lett., (2012) 22:4:1619 | ||||
Ki | 7.6 | Bioorg. Med. Chem. Lett., (2003) 13:20:3487 | ||||
Ki | 7.49 | J. Med. Chem., (1997) 40:20:3228 | ||||
Ki | 7.44 | J. Med. Chem., (1996) 39:20:3875 | ||||
Ki | 7.44 | J. Med. Chem., (2000) 43:20:3778 | ||||
Ki | 7.44 | Bioorg. Med. Chem. Lett., (2005) 15:18:4110 | ||||
CNR1
Cannabinoid receptor 1
21 Activities
Items per page:
1 – 10 of 21
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.55 | J. Nat. Prod., (2011) 74:10:2313 | ||||
Ki | 8.54 | Bioorg. Med. Chem. Lett., (2008) 18:13:3695 | ||||
Ki | 8.41 | J. Med. Chem., (2013) 56:11:4798 | ||||
Ki | 8.41 | MedChemComm, (2014) 5:5:632 | ||||
Ki | 8 | Bioorg. Med. Chem. Lett., (2012) 22:4:1619 | ||||
Ki | 7.77 | Bioorg. Med. Chem. Lett., (2007) 17:14:3925 | ||||
EC50 | 7.77 | Bioorg. Med. Chem. Lett., (2012) 22:4:1619 | ||||
Ki | 7.75 | J. Nat. Prod., (2015) 78:6:1271 | ||||
Ki | 7.66 | Eur. J. Med. Chem., (2014) 85:None:77 | ||||
Ki | 7.54 | Bioorg. Med. Chem. Lett., (2003) 13:20:3487 | ||||
GLRA1
Glycine receptor subunit alpha-1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.5 | |||||
EC50 | 5.89 | J. Med. Chem., (2015) 58:7:2958 | ||||
GLRA2
Glycine receptor subunit alpha-2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6 | |||||
GLRA3
Glycine receptor subunit alpha-3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.3 | |||||
GPR18
N-arachidonyl glycine receptor
1 Activities
GPR55
G-protein coupled receptor 55
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.1 | |||||
TRPA1
Transient receptor potential cation channel subfamily A member 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 4.9 | |||||
TRPV2
Transient receptor potential cation channel subfamily V member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 4.85 | |||||
DRD3
D(3) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7.99 | J Med Chem, (2017) 60:6:2287 | ||||