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disulfiram

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Synonyms & Links
PubChem: 3117
Guide to Pharmacology: 7168
DrugCentral: 928
LyCHI:  MHVHBJPNP3G7


Target Activities