diltiazem
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Ligand Summary
UNII: EE92BBP03H
PubChem: 39186
Guide to Pharmacology: 2298
ChEMBL: CHEMBL23
DrugCentral: 897
LyCHI: CV8BFLDQ99B6
Target Activities
CYP3A4
Cytochrome P450 3A4
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | J. Med. Chem., (2012) 55:11:4896 | ||||
IC50 | 7 | Drug Metab. Dispos., (2012) 40:7:1429 | ||||
IC50 | 7 | Drug Metab. Dispos., (2012) 40:7:1429 | ||||
Ki | 6.3 | Curr. Drug Metab., (2005) 6:1:413 | ||||
HTR3A
5-hydroxytryptamine receptor 3A
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.68 | |||||
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 4 | |||||
KCNA1
Potassium voltage-gated channel subfamily A member 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 3.8 | |||||
KCNA2
Potassium voltage-gated channel subfamily A member 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 3.7 | |||||
KCNA5
Potassium voltage-gated channel subfamily A member 5
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 3.9 | |||||
KCNA7
Potassium voltage-gated channel subfamily A member 7
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
4.2 | ||||||
KCNC1
Potassium voltage-gated channel subfamily C member 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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4 | ||||||
CACNA1S
Voltage-dependent L-type calcium channel subunit alpha-1S
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.42 | Bioorg. Med. Chem. Lett., (1993) 3:12:2797 | ||||
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.32 | BLOCKER | ||||