Pharos : Ligand Details

Target Activities

PTGS2

Tclin

Prostaglandin G/H synthase 2

20 Activities

Items per page:

1 – 10 of 20

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.7		17341061

IC50	8.3	J. Med. Chem., (2005) 48:22:6997	16250658

IC50	8.3	J. Med. Chem., (2012) 55:7:2932	22236250

IC50	8	Bioorg. Med. Chem., (2009) 17:2:558	19097798

IC50	7.7	J. Med. Chem., (2007) 50:7:1425	17341061

IC50	7.7	Bioorg. Med. Chem. Lett., (2014) 24:1:77	24332492

IC50	7.7	J. Med. Chem., (2016) 59:8:3920	27019010

IC50	7.7	Bioorg Med Chem, (2020) 28:2:115246	31843462

IC50	7.58	J. Med. Chem., (2005) 48:22:6997	16250658

IC50	7.55	J. Biol. Chem., (2007) 282:22:16379	17434872

PTGS1

Tclin

Prostaglandin G/H synthase 1

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.92		16252917

IC50	8.52	J. Med. Chem., (2012) 55:7:2932	22236250

IC50	8.52	Med Chem Res, (2011) 20:2:239

IC50	7.92	J. Med. Chem., (2008) 51:2:260	18095641

IC50	7.92	J. Med. Chem., (2009) 52:4:1115	19191553

IC50	7.92	J. Med. Chem., (2008) 51:20:6348	18811132

IC50	7.89	None, None:None:None

IC50	7.82	J. Med. Chem., (2008) 51:14:4150	18588282

IC50	7.52	J. Nat. Prod., (2005) 68:10:1514	16252917

IC50	7.16	J. Med. Chem., (2007) 50:7:1425	17341061

TRPM3

Tchem

Transient receptor potential cation channel subfamily M member 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	5.2			27433342

IC50	5.2	BLOCKER	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2714

CXCL8

Tchem

Interleukin-8

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.1	Bioorg. Med. Chem. Lett., (2009) 19:15:4026	19560921

IC50	8.1	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139

CXCR1

Tchem

C-X-C chemokine receptor type 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.92	Bioorg. Med. Chem. Lett., (2009) 19:15:4026	19560921

IC50	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139

ASIC3

Tchem

Acid-sensing ion channel 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	4

PPARG

Tclin

Peroxisome proliferator-activated receptor gamma

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	6.2			11752200

TTR

Tclin

Transthyretin

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6		J. Med. Chem., (2015) 58:16:6507	26214366