diclofenac
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Ligand Summary
UNII: 144O8QL0L1
PubChem: 3033
PubChem: 5018304
Guide to Pharmacology: 2714
ChEMBL: CHEMBL139
ChEMBL: CHEMBL1034
DrugCentral: 865
LyCHI: MUDSKU2U2VCB
Target Activities
PTGS2
Prostaglandin G/H synthase 2
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.7 | |||||
IC50 | 8.3 | J. Med. Chem., (2005) 48:22:6997 | ||||
IC50 | 8.3 | J. Med. Chem., (2012) 55:7:2932 | ||||
IC50 | 8 | Bioorg. Med. Chem., (2009) 17:2:558 | ||||
IC50 | 7.7 | J. Med. Chem., (2007) 50:7:1425 | ||||
IC50 | 7.7 | Bioorg. Med. Chem. Lett., (2014) 24:1:77 | ||||
IC50 | 7.7 | J. Med. Chem., (2016) 59:8:3920 | ||||
IC50 | 7.7 | Bioorg Med Chem, (2020) 28:2:115246 | ||||
IC50 | 7.58 | J. Med. Chem., (2005) 48:22:6997 | ||||
IC50 | 7.55 | J. Biol. Chem., (2007) 282:22:16379 | ||||
PTGS1
Prostaglandin G/H synthase 1
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.92 | |||||
IC50 | 8.52 | J. Med. Chem., (2012) 55:7:2932 | ||||
IC50 | 8.52 | Med Chem Res, (2011) 20:2:239 | ||||
IC50 | 7.92 | J. Med. Chem., (2008) 51:2:260 | ||||
IC50 | 7.92 | J. Med. Chem., (2009) 52:4:1115 | ||||
IC50 | 7.92 | J. Med. Chem., (2008) 51:20:6348 | ||||
IC50 | 7.89 | None, None:None:None | ||||
IC50 | 7.82 | J. Med. Chem., (2008) 51:14:4150 | ||||
IC50 | 7.52 | J. Nat. Prod., (2005) 68:10:1514 | ||||
IC50 | 7.16 | J. Med. Chem., (2007) 50:7:1425 | ||||
TRPM3
Transient receptor potential cation channel subfamily M member 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 5.2 | |||||
IC50 | 5.2 | BLOCKER | ||||
CXCL8
Interleukin-8
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.1 | Bioorg. Med. Chem. Lett., (2009) 19:15:4026 | ||||
IC50 | 8.1 | |||||
CXCR1
C-X-C chemokine receptor type 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.92 | Bioorg. Med. Chem. Lett., (2009) 19:15:4026 | ||||
IC50 | 7.92 | |||||
ASIC3
Acid-sensing ion channel 3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 4 | |||||
PPARG
Peroxisome proliferator-activated receptor gamma
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 6.2 | |||||
TTR
Transthyretin
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 6 | J. Med. Chem., (2015) 58:16:6507 | ||||