diazepam
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
Ligand Summary
Target Activities
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GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2
7 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.65 | POSITIVE ALLOSTERIC MODULATOR | ||||
EC50 | 7.1427 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.8539 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.9393 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.9586 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.0044 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRB2
Gamma-aminobutyric acid receptor subunit beta-2
6 Activities
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1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.6655 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 6.7055 | POSITIVE ALLOSTERIC MODULATOR | ||||
EC50 | 7.1427 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.9393 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.0044 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5
5 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.64 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 7.9586 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.0044 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
5 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.44 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 7.78999996 | |||||
Ki | 6.7055 | POSITIVE ALLOSTERIC MODULATOR | ||||
EC50 | 7.1427 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.8539 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.65 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.8539 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.9586 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.76999998 | |||||
Ki | 6.6655 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.65 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.9393 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRG3
Gamma-aminobutyric acid receptor subunit gamma-3
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.6655 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 6.7055 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 7.2034 | POSITIVE ALLOSTERIC MODULATOR | ||||
ADORA3
Adenosine receptor A3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.92 | J. Med. Chem., (2005) 48:22:6887 | ||||
IC50 | 7.92 | |||||
GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.76999998 | |||||
Ki | 7.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
TRHR
Thyrotropin-releasing hormone receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 5.15 | |||||