decitabine
Ligand Summary
An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.
UNII: 776B62CQ27
PubChem: 451668
ChEMBL: CHEMBL1201129
DrugCentral: 790
LyCHI: 7FVQT3S3U719
Target Activities
DNMT1
DNA (cytosine-5)-methyltransferase 1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.52 | J Med Chem, (2018) 61:15:6518 | ||||
IC50 | 7.52 | INHIBITOR | ||||
DNMT3A
DNA (cytosine-5)-methyltransferase 3A
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
INHIBITOR | ||||||