Pharos : Ligand Details

Target Activities

ABL1

Tclin

Tyrosine-protein kinase ABL1

31 Activities

Items per page:

1 – 10 of 31

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.85	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:33:13283	17684099

IC50	8.38	J. Med. Chem., (2007) 50:23:5853	17956080

IC50	8.4	Eur J Med Chem, (2016) 123:None:1	27474918

Kd	8.68	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.92	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.96	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.02	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.14	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.28	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	9.52	J. Med. Chem., (2013) 56:3:879	23301703

KIT

Tclin

Mast/stem cell growth factor receptor Kit

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.89	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:9:3520	17360676

IC50	8.3	J. Med. Chem., (2004) 47:27:6658	15615512

Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.57	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.59	Eur. J. Med. Chem., (2011) 46:6:2043	21429632

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.59	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.62	J. Med. Chem., (2013) 56:8:3281	23521020

Kd	8.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.09	Nat. Biotechnol., (2011) 29:11:1046	22037378

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.85	Bioorg. Med. Chem., (2009) 17:8:3152	19321350

Kd	7.96	Nat. Chem. Biol., (2009) 5:6:394	19396179

IC50	8.82	J. Med. Chem., (2007) 50:23:5853	17956080

IC50	9.22	Bioorg. Med. Chem., (2011) 19:8:2517	21459579

IC50	9.22	Bioorg. Med. Chem., (2009) 17:8:3152	19321350

IC50	9.22	J. Med. Chem., (2010) 53:4:1413	20166671

IC50	9.3	J. Med. Chem., (2004) 47:27:6658	15615512

IC50	9.3	J. Med. Chem., (2006) 49:23:6819	17154512

IC50	9.4	Nat. Chem. Biol., (2009) 5:6:394	19396179

IC50	9.52	J. Med. Chem., (2015) 58:9:3957	25835317

DDR2

Tchem

Discoidin domain-containing receptor 2

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.75	J. Med. Chem., (2014) 57:10:4252	24754677

IC50	7.93	J. Med. Chem., (2013) 56:8:3281	23521020

Kd	8.49	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.49	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.52	J. Med. Chem., (2014) 57:10:4252	24754677

IC50	8.7	ACS Med. Chem. Lett., (2015) 6:7:798	26191369

IC50	8.85	J. Med. Chem., (2015) 58:8:3287	25569119

IC50	9.4	J. Med. Chem., (2014) 57:10:4252	24754677

Kd	8.52	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1421

LCK

Tclin

Tyrosine-protein kinase Lck

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.4		J. Med. Chem., (2010) 53:4:1413	20166671

IC50	8.52		Bioorg. Med. Chem. Lett., (2011) 21:19:5870	21855335

IC50	9.4		J. Med. Chem., (2004) 47:27:6658	15615512

IC50	9.4		J. Med. Chem., (2006) 49:23:6819	17154512

Kd	9.7		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.7		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.7	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1421

YES1

Tclin

Tyrosine-protein kinase Yes

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.3		Bioorg. Med. Chem. Lett., (2013) 23:15:4398	23787099

IC50	9.3		J. Med. Chem., (2004) 47:27:6658	15615512

IC50	9.3		J. Med. Chem., (2006) 49:23:6819	17154512

Kd	9.52		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.52		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.52	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1421

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.32	J. Med. Chem., (2013) 56:8:3281	23521020

Kd	9.16	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.16	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	9.3	J. Med. Chem., (2015) 58:8:3287	25569119

Kd	9.16	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1421

BTK

Tclin

Tyrosine-protein kinase BTK

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3	J. Med. Chem., (2012) 55:10:4539	22394077

IC50	8.3	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:33:13283	17684099

Kd	8.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.85	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.89	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:33:13283	17684099

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.13	Bioorg. Med. Chem., (2010) 18:5:1789	20156689

IC50	8.3	J. Med. Chem., (2013) 56:17:6991	23937569

Kd	9.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.24	Nat. Biotechnol., (2008) 26:1:127	18183025

GAK

Tchem

Cyclin-G-associated kinase

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.59	J. Med. Chem., (2015) 58:8:3393	25822739

Kd	8.59	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.59	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1421

ABL1

Tyrosine-protein kinase ABL1

31 Activities

KIT

Mast/stem cell growth factor receptor Kit

17 Activities

SRC

Proto-oncogene tyrosine-protein kinase Src

15 Activities

DDR2

Discoidin domain-containing receptor 2

9 Activities

LCK

Tyrosine-protein kinase Lck

7 Activities

YES1

Tyrosine-protein kinase Yes

6 Activities

DDR1

Epithelial discoidin domain-containing receptor 1

5 Activities

BTK

Tyrosine-protein kinase BTK

5 Activities

CSF1R

Macrophage colony-stimulating factor 1 receptor

4 Activities

GAK

Cyclin-G-associated kinase

4 Activities

FYN

Tyrosine-protein kinase Fyn

4 Activities