dapagliflozin
an Sodium-glucose cotransporter 2 (SGLT2) inhibitor, SGLT2 expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen, by inhibiting SGLT2, dapagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion
Ligand Summary
UNII: 1ULL0QJ8UC
PubChem: 9887712
Guide to Pharmacology: 4594
ChEMBL: CHEMBL429910
DrugCentral: 4304
LyCHI: 2NSHZBU641RM
Target Activities
SLC5A2
Sodium/glucose cotransporter 2
38 Activities
Items per page:
1 – 10 of 38
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.3 | |||||
IC50 | 9.31 | Bioorg. Med. Chem., (2010) 18:6:2178 | ||||
IC50 | 9.31 | Bioorg. Med. Chem. Lett., (2010) 20:11:3420 | ||||
IC50 | 9.31 | Bioorg. Med. Chem., (2010) 18:16:6069 | ||||
IC50 | 9.31 | Bioorg. Med. Chem. Lett., (2010) 20:23:7046 | ||||
IC50 | 9.31 | Bioorg. Med. Chem. Lett., (2011) 21:2:742 | ||||
IC50 | 9.31 | ACS Med. Chem. Lett., (2011) 2:2:182 | ||||
IC50 | 9.31 | Eur. J. Med. Chem., (2011) 46:7:2662 | ||||
IC50 | 9.31 | Bioorg. Med. Chem., (2011) 19:19:5813 | ||||
IC50 | 9.1 | J Med Chem, (2017) 60:2:568 | ||||
SLC5A1
Sodium/glucose cotransporter 1
15 Activities
Items per page:
1 – 10 of 15
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.4 | |||||
IC50 | 8.49 | Bioorg. Med. Chem. Lett., (2011) 21:15:4465 | ||||
IC50 | 6.43 | Bioorg. Med. Chem. Lett., (2011) 21:8:2472 | ||||
EC50 | 6.37 | J. Med. Chem., (2011) 54:1:166 | ||||
EC50 | 6.23 | Eur. J. Med. Chem., (2012) 55:None:32 | ||||
IC50 | 6.2 | J Med Chem, (2017) 60:10:4173 | ||||
IC50 | 6.1 | Bioorg. Med. Chem., (2012) 20:13:4117 | ||||
IC50 | 6.1 | J. Med. Chem., (2012) 55:17:7828 | ||||
IC50 | 6.09 | J. Med. Chem., (2009) 52:20:6201 | ||||
IC50 | 6.09 | None, (2015) None:None:None | ||||
SLC5A11
Sodium/myo-inositol cotransporter 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.42 | Bioorg. Med. Chem. Lett., (2011) 21:8:2472 | ||||
IC50 | 6.42 | |||||
SLC5A4
Solute carrier family 5 member 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.87 | Bioorg. Med. Chem. Lett., (2011) 21:12:3759 | ||||
IC50 | 8.87 | |||||