You are using an outdated browser. Please upgrade your browser to improve your experience.

dacomitinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Dacomitinib is an irreversible inhibitor of the kinase activity of the human EGFR family (EGFR/HER1, HER2, and HER4) and certain EGFR activating mutations (exon 19 deletion or the exon 21 L858R substitution mutation). In vitro dacomitinib also inhibited the activity of DDR1, EPHA6, LCK, DDR2, and MNK1 at clinically relevant concentrations.
Synonyms & Links
Guide to Pharmacology: 7422
DrugCentral: 5297
LyCHI:  PSP3LBW32FKK


loading...
Target Activities