dabigatran etexilate
Ligand Summary
A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
UNII: 2E18WX195X
PubChem: 135565674
ChEMBL: CHEMBL539697
DrugCentral: 776
LyCHI: FLAWC2XFBW7X
Target Activities
F2
Prothrombin
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.58 | Bioorg. Med. Chem., (2016) 24:2:73 | ||||
IC50 | 8.58 | Bioorg. Med. Chem., (2016) 24:2:73 | ||||
Ki | 8.35 | Bioorg. Med. Chem. Lett., (2013) 23:7:2089 | ||||
Ki | 8.35 | INHIBITOR | ||||
HPN
Serine protease hepsin
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.08 | |||||
PRSS2
Trypsin-2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.3 | |||||
PRSS3
Trypsin-3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.3 | |||||