You are using an outdated browser. Please upgrade your browser to improve your experience.

cobimetinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase 1 (MEK1) and MEK2. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. BRAF V600E and K mutations result in constitutive activation of the BRAF pathway which includes MEK1 and MEK2. In mice implanted with tumor cell lines expressing BRAF V600E, cobimetinib inhibited tumor cell growth.
Synonyms & Links
Guide to Pharmacology: 7626
DrugCentral: 5046
LyCHI:  8UDBJA4F9RNN


Target Activities