clotrimazole
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Ligand Summary
UNII: G07GZ97H65
PubChem: 2812
Guide to Pharmacology: 2330
ChEMBL: CHEMBL104
DrugCentral: 719
LyCHI: MRC3NXQ97R3Y
Target Activities
NR1I3
Nuclear receptor subfamily 1 group I member 3
4 Activities
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.44 | J. Med. Chem., (2008) 51:4:976 | ||||
IC50 | 7.16 | Bioorg. Med. Chem. Lett., (2009) 19:8:2299 | ||||
IC50 | 7.16 | Bioorg. Med. Chem. Lett., (2009) 19:8:2299 | ||||
IC50 | 7.15 | |||||
CYP3A4
Cytochrome P450 3A4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | None, (2015) None:None:None | ||||
IC50 | 7.8 | None, None:None:None | ||||
CYP51A1
Lanosterol 14-alpha demethylase
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.89 | Drug Metab. Dispos., (2007) 35:3:493 | ||||
IC50 | 6.89 | |||||
KCNA3
Potassium voltage-gated channel subfamily A member 3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.22 | Bioorg. Med. Chem. Lett., (2009) 19:8:2299 | ||||
CYP19A1
Aromatase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.74 | Bioorg. Med. Chem. Lett., (2010) 20:10:3050 | ||||
CYP17A1
Steroid 17-alpha-hydroxylase/17,20 lyase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.09 | J. Med. Chem., (2003) 46:12:2345 | ||||
CYP2C19
Cytochrome P450 2C19
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | None, None:None:None | ||||
TBXAS1
Thromboxane-A synthase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.85 | None, None:None:None | ||||
CYP2C9
Cytochrome P450 2C9
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | None, None:None:None | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.52 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||